देश: ऑस्ट्रेलिया
भाषा: अंग्रेज़ी
स्रोत: Department of Health (Therapeutic Goods Administration)
azathioprine, Quantity: 25 mg
Strides Pharma Science Pty Ltd
Azathioprine
Tablet, film coated
Excipient Ingredients: microcrystalline cellulose; mannitol; maize starch; povidone; croscarmellose sodium; sodium stearylfumarate; titanium dioxide; hypromellose; iron oxide yellow; iron oxide red; iron oxide black; macrogol 400; macrogol 8000; sunset yellow FCF aluminium lake; carmine; indigo carmine aluminium lake
Oral
100 tablets
(S4) Prescription Only Medicine
Azathioprine is used as an immunosuppressant/antimetabolite either alone or, more commonly, in combination with the other agents (usually corticosteroids) and procedures which influence the immune response. Therapeutic effect may be evident only after weeks or months and can include a steroid sparing effect, thereby reducing the toxicity associated with high dosage and prolonged usage of corticosteroids. Azathioprine, in combination with corticosteroids and/or other immunosuppressive agents and procedures, is indicated in the management of patients receiving organ transplants. Azathioprine, either alone or more usually in combination with corticosteroids and/or other procedures, has been used with clinical benefit which may include reduction of dosage or discontinuation of corticosteroids, in a proportion of patients suffering from the following: Severe rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis,/polymyositis, autoimmune chronic active hepatitis, pemphigus vulgaris, polyarteritis nodosa, autoimmune haemolytic anaemia and chronic refractory idiopathic thromocytopenic purpura.
Visual Identification: A peach coloured, film coated, circular, biconvex tablet, engraved "AZA 25" on one face, the other face is plain.; Container Type: Blister Pack; Container Material: PVC/PE/PVDC/Al; Container Life Time: 1 Years; Container Temperature: Store below 30 degrees Celsius
Registered
2012-06-05
IMAZAN™ Consumer Medicine Information Azathioprine 25 mg and 50 mg tablets _ _ _ _ WHAT IS IN THIS LEAFLET THIS LEAFLET ANSWERS SOME OF THE COMMON QUESTIONS ABOUT IMAZAN. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. ALL MEDICINES HAVE RISKS AND BENEFITS. Your doctor has weighed the risks of you taking IMAZAN against the benefits the medicine is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. YOU MAY NEED TO READ IT AGAIN. WHAT IMAZAN IS USED FOR IMAZAN contains azathioprine. This belongs to a group of medicines called immune suppressants which work by reducing the body’s own natural immunity. IMAZAN is used to treat patients who have received an organ transplant to help prevent their body from rejecting the transplanted organs (e.g. a heart or kidney). IMAZAN is also used to suppress the body’s immunity to treat “autoimmune” conditions like rheumatoid arthritis, systemic lupus erythematosus or chronic active hepatitis.. IMAZAN may also be used to treat other conditions as determined by your doctor. IMAZAN IS A VERY POWERFUL MEDICINE. NEVER LET ANYONE ELSE TAKE YOUR MEDICINE EVEN IF HIS OR HER CONDITION SEEMS SIMILAR TO YOURS. HAVE REGULAR CHECK UPS WITH YOUR DOCTOR. IMAZAN TABLETS ARE NOT ADDICTIVE. BEFORE YOU TAKE IMAZAN _ _ _WHEN YOU MUST NOT TAKE IT: _ IF YOU ARE FEMALE AND YOU ARE PREGNANT OR THERE IS A CHANCE THAT YOU MAY BECOME PREGNANT; OR IF YOU ARE MALE AND THERE IS A CHANCE THAT YOU MAY FATHER A CHILD. IMAZAN is not recommended during pregnancy. IT MAY CAUSE BIRTH DEFECTS IF EITHER THE MALE OR FEMALE ARE USING IT AT THE TIME OF CONCEPTION. Your partner should take adequate contraceptive precautions while you are taking IMAZAN. IF YOU ARE BREASTFEEDING OR ARE PLANNING TO BREASTFEED. IMAZAN passes into breast milk and may cause serious side effects to your baby. IF YOU ARE TAKING ANY OTHER MEDICINES OR DRUGS. पूरा दस्तावेज़ पढ़ें
Page 1 of 11 PRODUCT INFORMATION IMAZAN 25 MG & 50 MG TABLETS NAME OF THE MEDICINE The active ingredient in IMAZAN is azathioprine. Chemical structure: _ _ Chemical formula:C 9 H 7 N 7 O 2 S CAS no.: 446-86-6 Chemical name: 6-[(1-methyl-4-nitro-1_H_-imidazol-5-yl)thio]-7_H_-purine. Molecular weight: 277.3. DESCRIPTION Azathioprine is a pale yellow powder. It is practically insoluble in water or ethanol (96%). It is soluble in dilute solutions of alkali hydroxides and sparingly soluble in dilute mineral acids. IMAZAN tablets also contain the following ingredients: microcrystalline cellulose, croscarmellose sodium, mannitol, povidone, sodium stearylfumarate, maize starch and 25 mg only: Opadry Buff OY-3682, Opadry Buff OY-3690 and Opadry OY-1315G. 50 mg only: Opadry clear OY-7240. PHARMACOLOGY Azathioprine is an imidazole derivative of 6-mercaptopurine (6-MP). It is rapidly broken down _in-vivo _into 6-MP and a methylnitro-imidazole moiety. The 6-MP readily crosses cell membranes and is converted intracellularly into a number of purine thioanalogues, which include the main active nucleotide, thioinosinic acid. The rate of conversion varies from one person to another. Nucleotides do not transverse cell membranes and therefore do not circulate in body fluids. Irrespective of whether it is given directly or is derived _in-vivo _from azathioprine, 6-MP is eliminated mainly as the inactive oxidised metabolite thiouric acid. This oxidation is brought about by xanthine oxidase, an enzyme that is inhibited by allopurinol. The activity of the methylnitroimidazole moiety has not been defined clearly. However, in Page 2 of 11 several systems it appears to modify the activity of azathioprine as compared with that of 6-MP. The determination of azathioprine or 6-MP plasma concentrations has no prognostic value as regards effectiveness or toxicity of these compounds. While the precise mode of action remains to be elucidated, some suggested mechanisms include: The release of 6-MP which acts as a purine antimetabolite; The पूरा दस्तावेज़ पढ़ें