HYDROCORTISONE ACETATE PRAMOXINE HCL cream

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

HYDROCORTISONE ACETATE (UNII: 3X7931PO74) (HYDROCORTISONE - UNII:WI4X0X7BPJ), PRAMOXINE HYDROCHLORIDE (UNII: 88AYB867L5) (PRAMOXINE - UNII:068X84E056)

थमां उपलब्ध:

AvPAK

प्रशासन का मार्ग:

TOPICAL

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION DRUG

चिकित्सीय संकेत:

Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

उत्पाद समीक्षा:

Hydrocortisone Acetate 2.5% and Pramoxine HCl 1% Cream is available as follows: 1 oz tube (NDC 50268-413-30)

प्राधिकरण का दर्जा:

unapproved drug other

उत्पाद विशेषताएं

HYDROCORTISONE ACETATE PRAMOXINE HCL- HYDROCORTISONE ACETATE
PRAMOXINE HCL CREAM
AVPAK
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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HYDROCORTISONE ACETATE 2.5% PRAMOXINE HCL 1% CREAM
RX ONLY
FOR EXTERNAL USE ONLY. NOT FOR OPHTHALMIC USE.
DESCRIPTION
Hydrocortisone Acetate 2.5% and Pramoxine HCl 1% Cream is a topical
preparation
containing hydrocortisone acetate 2.5% w/w and pramoxine hydrochloride
1% w/w in a
hydrophilic cream base containing cetyl alcohol, stearyl alcohol,
glycerin, glyceryl
stearate SE, mineral oil, PEG-100 stearate, phenoxyethanol, purified
water, white
petrolatum, and xanthan gum. Topical corticosteroids are
anti-inflammatory and anti-
pruritic agents. The structural formula, the chemical name, molecular
formula and
molecular weight for the active ingredients are presented below
hydrocortisone acetate
Pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11,
17-dihydroxy-, (11-beta)-
C
H
O
; mol. wt: 404.50
pramoxine hydrchloride
4-(3-(butoxyphenoxy)propyl)morpholine hydrochloride
C
H
NO
.HCl; mol. wt: 329.87
CLINICAL PHARMACOLOGY
Topical corticosteroids share anti-inflammatory, anti-pruritic and
vasoconstrictive
23
32
6
17
27
3
actions.
The mechanism of anti-inflammatory activity of topical corticosteroids
is unclear. Various
laboratory methods, including vasoconstrictor assays, are used to
compare and predict
potencies and/or clinical efficacies of the topical corticosteroids.
There is some evidence
to suggest that a recognizable correlation exists between
vasoconstrictor potency and
therapeutic efficacy in man.
Pramoxine hydrochloride is a topical anesthetic agent which provides
temporary relief
from itching and pain. It acts by stabilizing the neuronal membrane of
nerve endings
with which it comes into contact.
PHARMACOKINETICS
The extent of percutaneous absorption of topical corticosteroids is
determined by many
factors including the vehicle, the int