देश: ऑस्ट्रेलिया
भाषा: अंग्रेज़ी
स्रोत: Department of Health (Therapeutic Goods Administration)
ceftriaxone sodium
Pfizer Australia Pty Ltd
ceftriaxone sodium
Registered
Hospira TM Ceftriaxone Sodium for Injection Page 1 HOSPIRA TM CEFTRIAXONE SODIUM POWDER FOR INJECTION ceftriaxone sodium _(kef-try-AXE-own)_ CONSUMER MEDICINE INFORMATION _date of dispensing _ _ _ _Patient name _ _Pharmacist name _ _ _ _Patient address _ _Pharmacist address _ WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Hospira TM Ceftriaxone Sodium Powder for Injection. It does not contain all the available information. It does not take the place of talking to your doctor and pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you being given ceftriaxone against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT BEING GIVEN THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET. You may need to read it again. WHAT HOSPIRA TM CEFTRIAXONE SODIUM POWDER FOR INJECTION IS USED FOR Ceftriaxone is an antibiotic used to treat infections in different parts of the body caused by bacteria. It is also used to prevent infections following surgery. Ceftriaxone will not work against infections caused by viruses such as colds or the flu. Ceftriaxone belongs to a group of antibiotics called cephalosporins _(kef-a-low-SPOR-ins)._ These antibiotics work by killing the bacteria that are causing your infection. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is not addictive. This medicine is available only with a doctor’s prescription. BEFORE YOU ARE GIVEN HOSPIRA TM CEFTRIAXONE SODIUM POWDER FOR INJECTION _WHEN YOU MUST NOT BE _ _GIVEN IT _ _ _ HOSPIRA TM CEFTRIAXONE SODIUM POWDER FOR INJECTION SHOULD NOT BE GIVEN TO YOU IF YOU HAVE AN ALLERGY TO: • any medicine containing ceftriaxone • other cephalosporin antibiotics • any of the ingredients listed at the end of this leaflet. Some of the symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, li पूरा दस्तावेज़ पढ़ें
Product Information - Australia Version 1.0 Page 1 of 11 HOSPIRA™ CEFTRIAXONE SODIUM POWDER FOR INJECTION NAME OF THE MEDICINE Ceftriaxone sodium N S NH 2 O N H N OMe N S COONa S N N N O ONa Me H H O 3.5 H 2 O DESCRIPTION Hospira™ Ceftriaxone Sodium Powder for Injection is a sterile, semisynthetic, broad spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is Disodium (6R,7R)-7-[[(2Z)-(2-aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3- [[(2-methyl-6-oxido-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulphanyl]methyl]-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylate 3.5 hydrate. . The chemical formula of ceftriaxone sodium is C 18 H 16 N 8 Na 2 O 7 S 3 3 ½ H 2 O. It has a calculated molecular weight of 661.59 (CAS registry number: 104376-79-6). Ceftriaxone sodium is a white or yellowish crystalline powder which is very soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. The pH of a 5% aqueous solution is approximately 6 to 8. Ceftriaxone sodium solutions may be light yellow to amber coloured in colour. Hospira™ Ceftriaxone Sodium Powder for Injection contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity. PHARMACOLOGY PHARMACOKINETICS Ceftriaxone is absorbed poorly from the gastrointestinal tract. Average plasma concentrations of ceftriaxone following a single 30 minute intravenous (IV) infusion of a 0.5, 1 or 2 g dose and intramuscular (IM) administration of a single 0.5 or 1 g dose in healthy subjects are presented in Table 1. Product Information - Australia Version 1.0 Page 2 of 11 TABLE 1 AVERAGE CEFTRIAXONE PLASMA CONCENTRATIONS AFTER SINGLE DOSE ADMINISTRATION . DOSE/ ROUTE AVERAGE PLASMA CONCENTRATIONS (MICROGRAMS/ML) (TIME FORM END OF ADMINISTRATION) 0.5 hour 1 hour 2 hour 4 hour 6 hour 8 hour 12 hour 16 hour 24 hour 0.5 G I.V. 82 59 48 37 29 23 15 10 5 0.5 G I.M. 30 41 43 39 31 25 16 ND ND 1 G I.V. 151 111 88 67 53 43 28 18 9 1 G I.M. 40 68 76 68 56 44 29 ND ND 2 G I.V. 257 192 154 117 89 7 पूरा दस्तावेज़ पढ़ें