देश: संयुक्त राज्य
भाषा: अंग्रेज़ी
स्रोत: NLM (National Library of Medicine)
Enrofloxacin (UNII: 3DX3XEK1BN) (Enrofloxacin - UNII:3DX3XEK1BN)
Dechra Veterinary Products LLC
ORAL
PRESCRIPTION
INDICATIONS: Enroquin Flavored Tablets (enrofloxacin) are indicated for the management of diseases associated with bacteria susceptible to enrofloxacin. Enroquin Flavored Tablets are indicated for use in dogs and cats. CONTRAINDICATIONS: Enrofloxacin is contraindicated in dogs and cats known to be hypersensitive to quinolones. Dogs: Based on the studies discussed under the section on ANIMAL SAFETY SUMMARY, the use of enrofloxacin is contraindicated in small and medium breeds of dogs during the rapid growth phase (between 2 and 8 months of age). The safe use of enrofloxacin has not been established in large and giant breeds during the rapid growth phase. Large breeds may be in this phase for up to one year of age and the giant breeds for up to 18 months. In clinical field trials utilizing a daily oral dose of 5.0 mg/kg, there were no reports of lameness or joint problems in any breed. However, controlled studies with histological examination of the articular cartilage have not been conducted in the large or
HOW SUPPLIED:
Abbreviated New Animal Drug Application
ENROQUIN- ENROFLOXACIN TABLET, CHEWABLE DECHRA VETERINARY PRODUCTS LLC ---------- ENROQUIN™ FLAVORED TABLETS (ENROFLOXACIN) CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Federal law prohibits the extralabel use of this drug in food-producing animals. DESCRIPTION: Enrofloxacin is a synthetic chemotherapeutic agent from the class of the quinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria (See Tables I and II). It is rapidly absorbed from the digestive tract, penetrating into all measured body tissues and fluids (See Table III). Tablets are available in three sizes (22.7, 68 and 136 mg enrofloxacin). CHEMICAL NOMENCLATURE AND STRUCTURAL FORMULA: 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ACTIONS: MICROBIOLOGY: Quinolone carboxylic acid derivatives are classified as DNA gyrase inhibitors. The mechanism of action of these compounds is very complex and not yet fully understood. The site of action is bacterial gyrase, a synthesis promoting enzyme. The effect on _Escherichia coli_ is the inhibition of DNA synthesis through prevention of DNA supercoiling. Among other things, such compounds lead to the cessation of cell respiration and division. They may also interrupt bacterial membrane integrity. Enrofloxacin is bactericidal, with activity against both Gram negative and Gram positive bacteria. The minimum inhibitory concentrations (MICs) were determined for a series of 39 isolates representing 9 genera of bacteria from natural infections in dogs and cats, selected principally because of resistance to one or more of the following antibiotics: ampicillin, cephalothin, colistin, chloramphenicol, erythromycin, gentamicin, kanamycin, penicillin, streptomycin, tetracycline, triple sulfa and sulfa/trimethoprim. The MIC values for enrofloxacin against these isolates are presented in Table I. Most strains of these organisms were found to b पूरा दस्तावेज़ पढ़ें