ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE tablet

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

ENALAPRIL MALEATE (UNII: 9O25354EPJ) (ENALAPRILAT ANHYDROUS - UNII:Q508Q118JM)

थमां उपलब्ध:

Oceanside Pharmaceuticals

INN (इंटरनेशनल नाम):

ENALAPRIL MALEATE

रचना:

ENALAPRIL MALEATE 10 mg

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION DRUG

प्राधिकरण का दर्जा:

New Drug Application Authorized Generic

उत्पाद विशेषताएं

ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE- ENALAPRIL MALEATE AND
HYDROCHLOROTHIAZIDE TABLET
OCEANSIDE PHARMACEUTICALS
----------
ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE TABLETS
WARNING: FETAL TOXICITY
_SEE FULL PRESCRIBING INFORMATION FOR COMPLETE BOXED WARNING._
• WHEN PREGNANCY IS DETECTED, DISCONTINUE ENALAPRIL MALEATE AND
HYDROCHLOROTHIAZIDE
TABLETS AS SOON AS POSSIBLE.
• DRUGS THAT ACT DIRECTLY ON THE RENIN-ANGIOTENSIN SYSTEM CAN CAUSE
INJURY AND DEATH TO THE
DEVELOPING FETUS. SEE WARNINGS: FETAL TOXICITY
DESCRIPTION
Enalapril Maleate and Hydrochlorothiazide Tablets combine an
angiotensin converting enzyme inhibitor,
enalapril maleate, and a diuretic, hydrochlorothiazide.
Enalapril maleate is the maleate salt of enalapril, the ethyl ester of
a long-acting angiotensin converting
enzyme inhibitor, enalaprilat. Enalapril maleate is chemically
described as (_S_)-1-[_N_-[1-
(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline,
(_Z_)-2-butenedioate salt (1:1). Its empirical
formula is C
H N O •C H O , and its structural formula is:
Enalapril maleate is a white to off-white crystalline powder with a
molecular weight of 492.53. It is
sparingly soluble in water, soluble in ethanol, and freely soluble in
methanol.
Enalapril is a pro-drug; following oral administration, it is
bioactivated by hydrolysis of the ethyl ester
to enalaprilat, which is the active angiotensin converting enzyme
inhibitor.
Hydrochlorothiazide is
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide.
Its empirical formula is C H ClN O S and its structural formula is:
It is a white, or practically white, crystalline powder with a
molecular weight of 297.74, which is
slightly soluble in water, but freely soluble in sodium hydroxide
solution.
Enalapril Maleate and Hydrochlorothiazide Tablets are available in the
tablet combination of enalapril
maleate with hydrochlorothiazide:
Enalapril Maleate and Hydrochlorothiazide Tablets 10-25, containing 10
mg enalapril maleate and 25 mg
20
28
2
5
4
4
4
7
8
3
4
2
hydrochlorothiazid