DYNAPRIM TABLET

देश: मलेशिया

भाषा: अंग्रेज़ी

स्रोत: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

सक्रिय संघटक:

SULPHAMETHOXAZOLE; TRIMETHOPRIM

थमां उपलब्ध:

DYNAPHARM (M) SDN BHD

INN (इंटरनेशनल नाम):

SULPHAMETHOXAZOLE; TRIMETHOPRIM

पैकेज में यूनिट:

1000 Tablets; 100 Tablets

द्वारा बनाया गया:

DYNAPHARM (M) SDN BHD

सूचना पत्रक

Consumer Medication Information Leaflet (RiMUP)
DYNAPRIM TABLET
Sulphamethoxazole/Trimethoprim (400mg/80mg)
1
What is in this leaflet
1.
What Dynaprim Tablet is used for
2.
How Dynaprim Tablet works
3.
Before you use Dynaprim Tablet
4.
How to use Dynaprim Tablet
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Dynaprim
Tablet
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10. Date of revision
What Dynaprim Tablet is used for
Indicated in the treatment of:
- Condition that causes difficulty in
breathing as a result of constant
blocking of the airways in adults
- Inflammation of both the small
intestine and the colon
- Ear infection in children
- Infection on lungs
- Urinary tract infections
How Dynaprim Tablet works
Dynaprim Tablet contains
Sulphamethoxazole and Trimethoprim
which have enhanced antibacterial
activity.
Before you use Dynaprim Tablet
- When you must not use it
Do not use this medicine if:
- It is infants under 1 month of age.
- You have history of hypersensitivity to
Sulphamethoxazole or Trimethoprim.
- You have haematological (blood)
disorders, megaloblastic anaemia and
bone marrow changes or folic-acid
deficiency such as patients receiving
anticonvulsant drugs.
Pregnancy and lactation
Do not take Dynaprim Tablet if you are
pregnant, trying to get pregnant or think
you may be pregnant.
Do not take Dynaprim Tablet if you are
breast-feeding. Ask your doctor or
pharmacist for advice before taking any
medicine.
- Before you start use it
Tell your doctor or pharmacist if you
have:
- Impaired renal or hepatic functions
- G-6-PD deficiency (occurs when a
person is missing or does not have
enough of an enzyme called glucose-6-
phosphate dehydrogenase. This
enzyme helps red blood cells work
properly.)
- Folate deficiency
- Severe allergy or bronchial asthma.
- Taking other medicines
Tell your doctor if you are taking any
other medicines, including any that you
buy without a prescription from a
pharmacy, supermarket or health food
shop especially:
- Anticonvulsant

उत्पाद विशेषताएं

DYNAPRIM TABLET
MAL19910033AZ
DESCRIPTION:
TABLET
Colour
:
White
Shape
:
Round, flat and scored
Marking
:
“ST”
CONTENT:
Each Tablet Contains:
Sulphamethoxazole ..................... 400 mg
Trimethoprim ............................. 80 mg
PHARMACODYNAMICS:
Sulphamethoxazole and Trimethoprim interfere with the bacterial
synthesis of tetrahydrofolic acid, and essential stage in the
production of thymidine, purines, and subsequently nucleic acids.
Sulphamethoxazole, like the other sulphonamides, inhibits the
synthesis of dihydrofolic acid from p-aminobenzoic acid. Trimethoprim
inhibits the action of dihydrofolate reductase and
prevents the synthesis of tetrahydrofolic acid from dihydrofolic acid;
although this stage also occurs in man, Trimethoprim is
much less active against the mammalian enzyme. Enhanced antibacterial
activity has been reported when Sulphamethoxazole
and Trimethoprim are used together in vitro although there is doubt as
to whether sequential blockage of the bacterial synthetic
pathway is responsible. The clinical relevance of this enhanced
activity is uncertain especially in urinary-tract infections where
inhibitory concentrations of Trimethoprim appear to be dominant.
PHARMACOKINETICS:
Trimethoprim is readily absorbed from the GIT and peak concentrations
occur about 3 hours after a dose is taken. About 45% of
Trimethoprim is bound to plasma proteins. Tissue concentrations are
reported to be higher than serum concentrations, with
particularly high concentrations occurring in the kidneys and lungs
but concentrations in the cerebrospinal fluid are about one-
half of those in the blood. The half-life is about 10 to 16 hours.
About 40 to 50% of a dose is excreted unchanged in the urine
within 24 hours, together with metabolites. Trimethoprim appears in
breast milk.
Sulphamethoxazole is readily absorbed from the GIT and peak plasma
concentrations are reached within 4 hours. Doses of 1 g
twice daily should produce blood concentrations of unconjugated
Sulphamethoxazole in excess of 50 mcg per ml. Abou