DOXYCYCLINE HYCLATE tablet, film coated

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

Doxycycline Hyclate (UNII: 19XTS3T51U) (doxycycline anhydrous - UNII:334895S862)

थमां उपलब्ध:

Apothecary Shop Wholesale Inc.

INN (इंटरनेशनल नाम):

Doxycycline Hyclate

रचना:

Doxycycline Hyclate 100 mg

प्रशासन का मार्ग:

ORAL

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION DRUG

चिकित्सीय संकेत:

To reduce the development of drug-resistant bacteria and maintain effectiveness of doxycycline hyclate and other antibacterial drugs, doxycycline hyclate should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Doxycycline is indicated for the treatment of the following infections: -  Rocky Mountain spotted fever, typhus fever and the typhus group, Q. fever, rickettsialpox, and tick fevers caused by Rickettsiae. -  Respiratory tract infections caused by Mycoplasma pneumoniae. -  Lymphogranuloma venereum caused by Chlamydia trachomatis. -  Psittacosis (ornithosis) caused by Chlamydia psittaci. -  Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always el

उत्पाद समीक्षा:

Doxycycline Hyclate Tablets USP, equivalent to 100 mg doxycycline: Orange Coated, Round, Unscored Tablets Debossed "WW 112". Store at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.

प्राधिकरण का दर्जा:

Abbreviated New Drug Application

उत्पाद विशेषताएं

DOXYCYCLINE HYCLATE- DOXYCYCLINE HYCLATE TABLET, FILM COATED
APOTHECARY SHOP WHOLESALE INC.
----------
DOXYCYCLINE HYCLATE
TABLETS, USP
REV. 10/08
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of Doxycycline and
other antibacterial drugs, Doxycycline should be used only to treat or
prevent infections that are proven
or strongly suspected to be caused by bacteria.
DESCRIPTION
Doxycycline hyclate is a broad-spectrum antibiotic synthetically
derived from oxytetracycline. The
chemical designation is
4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-
6-methyl-1,11-dioxo-2-naphthacene-carboxamide monohydrochloride,
compound with ethyl alcohol
(2:1), monohydrate. Doxycycline is a light-yellow crystalline powder.
Doxycycline Hyclate is soluble
in water.
Doxycycline has a high degree of lipoid solubility and a low affinity
for calcium binding. It is highly
stable in normal human serum. Doxycycline will not degrade into an
epianhydro form.
The structural formula is as follows:
Each tablet for oral administration contains doxycycline hyclate
equivalent to 100 mg of doxycycline
(anhydrous). Inactive ingredients are: Colloidal Silicon Dioxide, Corn
Starch, Croscarmellose Sodium,
Docusate Sodium, Magnesium Stearate, and Microcrystalline Cellulose.
Film Coating and Polishing
contains: FD&C Blue No. 2, FD&C Yellow No. 6, and Titanium Dioxide.
CLINICAL PHARMACOLOGY
Tetracyclines are readily absorbed and are bound to plasma proteins in
varying degree. They are
concentrated by the liver in the bile, and excreted in the urine and
feces at high concentrations and in a
biologically active form. Doxycycline is virtually completely absorbed
after oral administration.
Following a 200 mg dose, normal adult volunteers averaged peak serum
levels of 2.6 mcg/mL of
doxycycline at 2 hours decreasing to 1.45 mcg/mL at 24 hours.
Excretion of doxycycline by the kidney
is about 40%/72 hours in individuals with normal function (creatinine
clearance about 75 mL/min). This
percent