DOMOSO Solution

देश: कनाडा

भाषा: फ़्रेंच

स्रोत: Health Canada

सक्रिय संघटक:

Diméthylsulfoxyde

थमां उपलब्ध:

ZOETIS CANADA INC

डोज़:

90%

फार्मास्यूटिकल फॉर्म:

Solution

रचना:

Diméthylsulfoxyde 90%

प्रशासन का मार्ग:

Topique

पैकेज में यूनिट:

480ML

प्रिस्क्रिप्शन प्रकार:

Prescription

चिकित्सीय समूह:

Chevaux; Chiens

उत्पाद समीक्षा:

Numéro de groupe d'ingrédients actifs (GIA) :0103075003

प्राधिकरण का दर्जा:

APPROUVÉ

प्राधिकरण की तारीख:

2007-01-08

उत्पाद विशेषताएं

GENERAL
Dimethyl
sulfoxide (DMSO),
an oxidation product
of
dimethyl
sulfide,
is an exceptional
solvent
possessing a
number of commercial uses.
DMSO is the lowest member of the group of alkyl sulfoxides with a
general formula of RSOR. Its structural formula
is:
It freely mixes with water with the evolution of heat and lowers the
freezing point of aqueous solutions. It is
soluble in many other compounds including ethanol, acetone, diethyl
ether, glycerin, toluene, benzene and
chloroform. DMSO is a solvent for many aromatic and unsaturated
hydrocarbons as well as inorganic salts and
nitrogen-containing compounds. DMSO has a high dielectric constant due
to the polarity of the sulphur-oxygen bond.
Its basicity is slightly greater than water due to enhanced electron
density at the oxygen atom. It forms crystalline
salts with strong protic acids and coordinates with Lewis acids. It
modifies hydrogen bonding.
DMSO is a hygroscopic stable organic liquid essentially odorless and
water white in color. Other physical
characteristics include:
Molecular weight
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
78.13
Melting point
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
18.45°C
Boiling point
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
189°C
Each mL of DOMOSO Solution contains 90% v/v dimethyl sulfoxide and
10.0% water.
METABOLISM
Dimethyl sulfoxide when administered topically or orally is rapidly
absorbed and distributed in living material.
Using S
35
-labeled DMSO (1) the maximal
blood concentration after cutaneous application was achieved in
approximately 10 minutes in rats and less than 1 hour in dogs. In rats
and dogs the substance did not accumulate in
the organs but the concentration in the treated skin and underlying
muscle was increased. The main route of excretion
is via the urine partially dependent on the species and route of
application. In rats there was no significant difference
in the elimination half time of 6 to 8 hours after intravenous or
cutaneou