DILTIAZEM HYDROCHLORIDE capsule extended release

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

DILTIAZEM HYDROCHLORIDE (UNII: OLH94387TE) (DILTIAZEM - UNII:EE92BBP03H)

थमां उपलब्ध:

St Marys Medical Park Pharmacy

INN (इंटरनेशनल नाम):

DILTIAZEM HYDROCHLORIDE

रचना:

DILTIAZEM HYDROCHLORIDE 240 mg

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION DRUG

प्राधिकरण का दर्जा:

Abbreviated New Drug Application

उत्पाद विशेषताएं

DILTIAZEM HYDROCHLORIDE- DILTIAZEM HYDROCHLORIDE CAPSULE, EXTENDED
RELEASE
ST MARYS MEDICAL PARK PHARMACY
----------
DILTIAZEM HYDROCHLORIDE EXTENDED-RELEASE CAPSULES, USP [ONCE-A-DAY
DOSAGE]
DESCRIPTION
Diltiazem hydrochloride is a calcium ion cellular influx inhibitor
(slow channel blocker or calcium
antagonist). Chemically, diltiazem hydrochloride is
1,5-benzothiazepin-4(5H)one, 3-(acetyloxy)-5-[2-
(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,
monohydrochloride,(+)-cis-. The chemical
structure is:
Diltiazem hydrochloride is a white to off-white crystalline powder
with a bitter taste. It is soluble in
water, formic acid, methanol, and chloroform. It has a molecular
weight of 450.98. Diltiazem
hydrochloride extended-release capsule, USP (Once-a-day dosage) is
formulated as a once-a-day
extended-release capsule containing 120 mg, 180 mg, 240 mg, 300 mg, or
360 mg diltiazem
hydrochloride, USP. The 120 mg, 180 mg, 240 mg, 300 mg and 360 mg
contain: sugar spheres,
hypromellose, talc, ethylcellulose, triethyl citrate, ammonio
methacrylate copolymer dispersion type B,
acetyl tributyl citrate, polysorbate 80, and magnesium stearate. The
capsule shells contain gelatin,
sodium lauryl sulfate, titanium dioxide, FD & C Blue 1 and iron oxide
black (180 mg, 240 mg, 300 mg
and 360 mg).
Imprinting ink contains shellac, dehydrated alcohol, isopropyl
alcohol, butyl alcohol, propylene glycol,
strong ammonia solution, black iron oxide, potassium hydroxide, and
purified water.
For oral administration. USP dissolution test pending.
CLINICAL PHARMACOLOGY
The therapeutic effects of diltiazem hydrochloride are believed to be
related to its ability to inhibit the
cellular influx of calcium ions during membrane depolarization of
cardiac and vascular smooth muscle.
MECHANISMS OF ACTION
HYPERTENSION. Diltiazem produces its antihypertensive effect primarily
by relaxation of vascular
smooth muscle and the resultant decrease in peripheral vascular
resistance. The magnitude of blood
pressure reduction is related to the degree of hyp