DEXAMETHASONE elixir

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

Dexamethasone (UNII: 7S5I7G3JQL) (Dexamethasone - UNII:7S5I7G3JQL)

थमां उपलब्ध:

Cardinal Health

INN (इंटरनेशनल नाम):

Dexamethasone

रचना:

Dexamethasone 0.5 mg in 5 mL

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION DRUG

प्राधिकरण का दर्जा:

Abbreviated New Drug Application

उत्पाद विशेषताएं

DEXAMETHASONE- DEXAMETHASONE ELIXIR
CARDINAL HEALTH
----------
DEXAMETHASONE ELIXIR, USP
(0.5 MG/5 ML)
RX ONLY
DESCRIPTION
EACH 5 ML (TEASPOONFUL) CONTAINS:
Dexamethasone, USP 0.5 mg
ALSO CONTAINS:
Benzoic Acid, USP 0.1%
(as preservative)
Alcohol 5.1%
INACTIVE INGREDIENTS: Artificial Raspberry Flavor; Citric Acid, USP;
FD&C Red No. 40; Liquid Sugar;
Propylene Glycol, USP and Purified Water, USP. IT MAY ALSO CONTAIN
Sodium Citrate, USP.
Glucocorticoids are adrenocortical steroids, both naturally occurring
and synthetic, which are readily
absorbed from the gastrointestinal tract.
Dexamethasone, a synthetic adrenocortical steroid, is a white to
practically white, odorless, crystalline
powder. It is stable in air. It is practically insoluble in water. The
molecular weight is 392.47. It is
designated chemically as
9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione.
The
molecular formula is C
H FO and the structural formula is:
CLINICAL PHARMACOLOGY
Naturally occurring glucocorticoids, (hydrocortisone and cortisone),
which also have salt-retaining
properties, are used as replacement therapy in adrenocortical
deficiency states. Their synthetic analogs,
including dexamethasone, are primarily used for their potent
antiinflammatory effects in disorders of
many organ systems.
Glucocorticoids cause profound and varied metabolic effects. In
addition, they modify the body's
immune responses to diverse stimuli.
At equipotent anti-inflammatory doses, dexamethasone almost completely
lacks the sodium-retaining
property of hydrocortisone and closely related derivatives of
hydrocortisone.
INDICATIONS AND USAGE
1. _ Endocrine Disorders: _Primary or secondary adrenocortical
insufficiency (hydrocortisone or
22
29
5
cortisone is the first choice; synthetic analogs may be used in
conjunction with mineralocorticoids
where applicable; in infancy mineralocorticoid supplementation is of
particular importance).
Congenital adrenal hyperplasia
Nonsuppurative thyroiditis
Hypercalcemia associated with cancer
2. _ Rheumatic Diso