देश: संयुक्त राज्य
भाषा: अंग्रेज़ी
स्रोत: NLM (National Library of Medicine)
DORAMECTIN (UNII: KGD7A54H5P) (DORAMECTIN - UNII:KGD7A54H5P)
Zoetis Inc.
DORAMECTIN
DORAMECTIN 10 mg in 1 mL
INTRAMUSCULAR
OTC
Dectomax injectable solution is indicated for the treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, eyeworms, grubs (see PRECAUTIONS), sucking lice (see PRECAUTIONS), and mange mites. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Lungworms (adults and fourth stage larvae) Dictyocaulus viviparus Eyeworms (adults) Thelazia spp. Grubs (parasitic stages) Hypoderma bovis H. lineatum Sucking Lice Haematopinus eurysternus Linognathus vituli Solenopotes capillatus Mange Mites Psoroptes bovis Sarcoptes scabiei 1 Adults Dectomax injectable solution has been proved to effectively control infections and to protect cattle from reinfection with Cooperia oncophora and Haemonchus placei for 14 days, Ostertagia ostertagi for 21 days, and C. punctata , Oesophagostomum radiatum , and Dictyocaulus viviparus for 28 days after treatment. Dectomax injectable solution is indicated for the treatment and control of the following species of gastrointestinal roundworms, lungworms, kidney worms, sucking lice (see PRECAUTIONS), and mange mites. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.
Dectomax is available in 100-mL, 200-mL, and 500-mL multi-dose, rubber-capped glass vials.
New Animal Drug Application
DECTOMAX- DORAMECTIN INJECTION, SOLUTION ZOETIS INC. ---------- DECTOMAX (DORAMECTIN INJECTION) ANTIPARASITIC _1% INJECTABLE SOLUTION FOR CATTLE AND SWINE_ _10 MG/ML_ Approved by FDA under NADA # 141-061 PRODUCT DESCRIPTION Dectomax injectable solution is a ready-to-use, colorless to pale yellow, sterile solution containing 1% w/v doramectin (10 mg/mL). In cattle, Dectomax is formulated to deliver the recommended dosage (200 mcg/kg of body weight) when given by subcutaneous (SC) or intramuscular (IM) injection at the rate of 1 mL/110 lb of body weight. In swine, Dectomax is formulated to deliver the recommended dosage (300 mcg/kg of body weight) when given by IM injection at the rate of 1 mL/75 lb of body weight. PRODUCT CHARACTERISTICS Dectomax injectable solution is a highly active, broad-spectrum parasiticide for parenteral administration to cattle and swine. It contains doramectin, a novel fermentation-derived macrocyclic lactone. Doramectin is isolated from fermentations of selected strains derived from the soil organism _Streptomyces avermitilis._ A primary mode of action of macrocyclic lactones is to modulate chloride ion channel activity in the nervous system of nematodes and arthropods. Macrocyclic lactones bind to receptors that increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods and causes paralysis and death of the parasites. In mammals, the neuronal receptors to which macrocyclic lactones bind are localized within the central nervous system (CNS), a site reached by only negligible concentrations of doramectin. One dose of Dectomax injectable solution effectively treats and controls a wide range of roundworm and arthropod parasites that impair the health and productivity of cattle and swine. Studies have demonstrated the safety margin of Dectomax injection in cattle and swine. In USA trials, no toxic signs were seen in cattle given up to 25 times the recommended dose, or in swine given up to 10 times the reco पूरा दस्तावेज़ पढ़ें