देश: ऑस्ट्रेलिया
भाषा: अंग्रेज़ी
स्रोत: Department of Health (Therapeutic Goods Administration)
cisatracurium besilate
Pfizer Australia Pty Ltd
cisatracurium besilate
Registered
________________________________________________________________________________ DBL™ Cisatracurium Injection Concentrate 1 DBL™ CISATRACURIUM INJECTION CONCENTRATE _ _ _Cisatracurium besilate (sis-at-rah-CURE-e-um BESS-ee-late) _ CONSUMER MEDICINE INFORMATION _Date of Dispensing_ _Consumer Name _ _ _ _ _ _ _ _ _ _ _ _Pharmacist Name _ _Consumer Address _ _ _ _ _ _ _ _ _ _Pharmacist Address _ _Consumer Address _ _ _ _ _ _ _ _ _ _Pharmacist Address _ WHAT IS IN THIS LEAFLET This leaflet answers some common questions about DBL™ Cisatracurium Injection Concentrate (cisatracurium besilate). It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you being given this medicine against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT BEING GIVEN THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT DBL™ CISATRACURIUM INJECTION CONCENTRATE IS USED FOR This medicine is used to relax the body’s muscles during surgery or other medical procedures. The medicine contains cisatracurium besilate, which belongs to a family of medicines called neuromuscular blockers. The medicine works by blocking the effects of one of the body’s chemical messengers called acetylcholine. Acetycholine is involved in muscle contraction. By relaxing your body’s muscles cisatracurium besilate makes it easier for you to be kept asleep (under anaesthesia) or sedation. Cisatracurium besilate is only used in conjunction with an anaesthetic, so you will be asleep during the procedure. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is not addictive. It is only available with a doctor’s prescription. BEFORE YOU ARE GIVEN DBL™ CISATRACURIUM INJECTION CONCENTRATE _WHEN YOU MUST NOT BE GIVEN _ _IT _ पूरा दस्तावेज़ पढ़ें
Product Information - Australia Version 2.0 - 1 - DBL TM CISATRACURIUM INJECTION CONCENTRATE NAME OF MEDICINE Cisatracurium besilate DESCRIPTION The active ingredient, Cisatracurium besilate, is a white to off-white or yellowish powder. DBL TM Cisatracurium Injection Concentrate is presented as a clear, colourless or faint yellow solution containing cisatracurium besilate, benzenesulfonic acid and water for injections, pH is 3.0 – 3.7. It contains no antimicrobial preservative. DBL TM Cisatracurium Injection Concentrate is available in the following presentations: Cisatracurium (as besilate salt), 5 mg per 2.5 mL Cisatracurium (as besilate salt), 10 mg per 5 mL Chemical name: (1R,1’R,2R,2’R)-2,2’- (3,11-dioxo-4, 10-dioxatridecamethylene)-_bis_- (1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratry-lisoquinolinium) dibenzenesulfonate. Molecular formula: C 65 H 82 N 2 O 18 S 2 Molecular weight: 1,243.5 CAS number: 96946-42-8 Product Information - Australia Version 2.0 - 2 - The structural formula of cisatracurium besilate is shown below:- ACTIONS Cisatracurium besilate, a stereoisomer of atracurium, is an intermediate duration, nondepolarising benzylisoquinolinium skeletal muscle relaxant. PHARMACOLOGY PHARMACODYNAMICS Cisatracurium besilate binds to cholinergic receptions on the motor endplate to antagonise the action of acetylcholine, resulting in a competitive block of neuromuscular transmission. This action is readily reversed by anticholinesterase agents such as neostigmine. The ED 95 (dose required to produce 95% depression of the twitch response of the adductor pollicis muscle to stimulation of the ulnar nerve) of cisatracurium besilate is estimated to be 0.05 mg/kg bodyweight during opioid anaesthesia (thiopentone, fentanyl, midazolam). The recommended intubation dose for cisatracurium besilate in adults is three times the ED 95 , which has a longer clinically effective duration than the recommended intubation dose of atracurium (two times the ED 95 ) (SEE DOSAGE AND ADMINISTRATION). The ED 95 of cis पूरा दस्तावेज़ पढ़ें