CHLORDIAZEPOXIDE HYDROCHLORIDE AND CLIDINIUM BROMIDE capsule

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

chlordiazepoxide hydrochloride (UNII: MFM6K1XWDK) (chlordiazepoxide - UNII:6RZ6XEZ3CR), clidinium bromide (UNII: 91ZQW5JF1Z) (clidinium - UNII:BO76JF850N)

थमां उपलब्ध:

Avera McKennan Hospital

INN (इंटरनेशनल नाम):

chlordiazepoxide hydrochloride

रचना:

chlordiazepoxide hydrochloride 5 mg

प्रशासन का मार्ग:

ORAL

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION DRUG

चिकित्सीय संकेत:

Based on a review of this drug by the National Academy of Sciences — National Research Council and/or other information, FDA has classified the indications as follows: "Possibly" effective: as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis. Final classification of the less-than-effective indications requires further investigation. Chlordiazepoxide HCl/Clidinium Bromide is contraindicated in the presence of glaucoma (since the anticholinergic component may produce some degree of mydriasis) and in patients with prostatic hypertrophy and benign bladder neck obstruction. It is contraindicated in patients with known hypersensitivity to chlordiazepoxide hydrochloride and/or clidinium bromide. Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt disc

उत्पाद समीक्षा:

Chlordiazepoxide HCl/Clidinium Bromide is available in light green opaque capsules, each containing 5 mg chlordiazepoxide hydrochloride and 2.5 mg clidinium bromide — bottles of 100 (NDC 68682-409-10), with OPI imprinted on the cap of the capsule and 409 imprinted on the body of the capsule. NDC 69189-0489-1 single dose pack with 1 capsule as repackaged by Avera McKennan Hospital Store at 25°C (77°F); excursions permitted to 15°C - 30°C (59°F - 86°F).

प्राधिकरण का दर्जा:

New Drug Application Authorized Generic

उत्पाद विशेषताएं

CHLORDIAZEPOXIDE HYDROCHLORIDE AND CLIDINIUM BROMIDE- CHLORDIAZEPOXIDE
HYDROCHLORIDE AND CLIDINIUM BROMIDE CAPSULE
AVERA MCKENNAN HOSPITAL
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CHLORDIAZEPOXIDE HCL/
CLIDINIUM BROMIDE
CAPSULES
_to control emotional_
_and somatic factors_
_in gastrointestinal disorders_
DESCRIPTION
Chlordiazepoxide HCl/Clidinium Bromide combines in a single capsule
formulation the antianxiety
action of chlordiazepoxide hydrochloride and the
anticholinergic/spasmolytic effects of clidinium
bromide, both exclusive developments of Roche research.
Each Chlordiazepoxide HCl/Clidinium Bromide capsule contains 5 mg
chlordiazepoxide hydrochloride
and 2.5 mg clidinium bromide. Each capsule also contains corn starch,
lactose and talc. Gelatin capsule
shells may contain methyl and propyl parabens and potassium sorbate,
with the following dye systems:
D&C Yellow No. 10 and either FD&C Blue No. 1 or FD&C Green No. 3.
Chlordiazepoxide hydrochloride is a versatile, therapeutic agent of
proven value for the relief of
anxiety and tension. It is indicated when anxiety, tension or
apprehension are significant components of
the clinical profile. It is among the safer of the effective
psychopharmacologic compounds.
Chlordiazepoxide hydrochloride is
7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide
hydrochloride. A colorless, crystalline substance, it is soluble in
water. It is unstable in solution and the
powder must be protected from light. The molecular weight is 336.22.
The structural formula of
chlordiazepoxide hydrochloride is as follows:
Clidinium bromide is a synthetic anticholinergic agent which has been
shown in experimental and
clinical studies to have a pronounced antispasmodic and antisecretory
effect on the gastrointestinal tract.
Structurally clidinium bromide is:
ANIMAL PHARMACOLOGY
Chlordiazepoxide hydrochloride has been studied extensively in many
species of animals and these
studies are suggestive of action on the limbic system of the brain,
which recent evidence indicates is
involved in emotional responses.
Hostile