ATROVENT N METERED DOSE INHALER 20MCGPUFF
देश: मलेशिया
भाषा: अंग्रेज़ी
स्रोत: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
उत्पाद विशेषताएं
(SPC)
13-06-2023
इस उत्पाद के लिए कुछ दस्तावेज़ वर्तमान में उपलब्ध नहीं हैं, आप हमारी ग्राहक सेवा को अनुरोध भेज सकते हैं और जैसे ही हम उन्हें प्राप्त करने में सक्षम होंगे, हम आपको सूचित करेंगे।
अनुरोध भेजा।
अनुरोध भेजा।
सक्रिय संघटक:
IPRATROPIUM BROMIDE
थमां उपलब्ध:
BOEHRINGER INGELHEIM (MALAYSIA) SDN. BHD.
INN (इंटरनेशनल नाम):
IPRATROPIUM BROMIDE
पैकेज में यूनिट:
10ml mL
द्वारा बनाया गया:
BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG
उत्पाद विशेषताएं
ATROVENT
®
ABCD
COMPOSITION
For
ATROVENT
®
20
mcg/puff Metered Dose Inhaler
1 metered dose (puff) contains 21 mcg (8r)-3
-hydroxy-8-isopropyl-1
H,5
H-tropanium bromide (
)-tropate monohydrate
(= ipratropium bromide monohydrate) corresponding to 20mcg ipratropium
bromide anhydrous.
Excipients
Propellant: 1,1,1,2-Tetrafluoroethane (HFA [hydrofluoralkane] 134a)
Other excipients: citric acid anhydrous, water purified, ethanol
anhydrous, nitrogen (inert gas)
For ATROVENT
®
0.025 % Nebuliser Solution
1 mL (20 drops) nebuliser solution contains 261mcg (8r)-3
-hydroxy-8-isopropyl-1
H,5
H-tropanium bromide (
)-tropate
monohydrate (= ipratropium bromide monohydrate) corresponding to 250
mcg ipratropium bromide anhydrous
Excipients: benzalkonium chloride, disodium edetate dihydrate, sodium
chloride, hydrochloric acid, purified water
DESCRIPTION
For
ATROVENT
®
20
mcg/puff Metered Dose Inhaler
Clear, colourless liquid, free from suspended particles
For ATROVENT
®
0.025 % Nebuliser Solution
Clear, colourless or almost colourless liquid, free from suspended
particles
PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: Anticholinergics
ATC Code : R03BB01
Mode of action
ATROVENT
®
(ipratropium bromide) is a quaternary ammonium compound with
anticholinergic (parasympatholytic)
properties. In non-clinical studies, it appears to inhibit vagally
mediated reflexes by antagonizing the action of
acetylcholine, the transmitter agent released from the vagus nerve.
Anticholinergics prevent the increase in intracellular
concentration of Ca++ which is caused by interaction of acetylcholine
with the muscarinic receptor on bronchial smooth
muscle.
Ca++ release is mediated by the second messenger system consisting of
IP3 (inositol triphosphate) and DAG
(diacylglycerol).
The bronchodilation following inhalation of ATROVENT
®
(ipratropium bromide) is primarily local and site specific to
the lung and not systemic in nature.
Non-clinical and clinical evidence suggest no deleterious effect of
ATROVENT
®
(ipr
पूरा दस्तावेज़ पढ़ें
