ALBON- sulfadimethoxine suspension

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

SULFADIMETHOXINE (UNII: 30CPC5LDEX) (SULFADIMETHOXINE - UNII:30CPC5LDEX)

थमां उपलब्ध:

Zoetis Inc.

INN (इंटरनेशनल नाम):

SULFADIMETHOXINE

रचना:

SULFADIMETHOXINE 250 mg in 5 mL

प्रशासन का मार्ग:

ORAL

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION

चिकित्सीय संकेत:

For the treatment of sulfadimethoxine-sensitive bacterial infections in dogs and cats and bacterial enteritis associated with coccidiosis in dogs. Albon is indicated for the treatment of respiratory, genitourinary tract, enteric, and soft tissue infections in dogs and cats: - tonsillitis - pharyngitis - bronchitis - pneumonia - cystitis - nephritis - metritis - pyometra - pustular dermatitis - anal gland infections - abscesses - wound infections - bacterial enteritis - canine salmonellosis - bacterial enteritis associated with coccidiosis in dogs when caused by streptococci, staphylococci, escherichia, salmonella, klebsiella, proteus or shigella organisms sensitive to sulfadimethoxine. Limitations:  Sulfadimethoxine is not effective in viral or rickettsial infections, and as with any antibacterial agent, occasional failures in therapy may occur due to resistant microorganisms. The usual precautions in sulfonamide therapy should be observed.

उत्पाद समीक्षा:

Albon Oral Suspension is available in 60- and 473-mL bottles; each tsp (5 mL) contains 250 mg sulfadimethoxine in a custard-flavored carrier.

प्राधिकरण का दर्जा:

New Animal Drug Application

उत्पाद विशेषताएं

ALBON- SULFADIMETHOXINE SUSPENSION
ZOETIS INC.
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ALBON (S ULFADIMETHOXINE)
ALBON
(_SULFADIMETHOXINE_)
ORAL SUSPENSION 5%
For the treatment of sulfadimethoxine-sensitive bacterial infections
in dogs and cats and bacterial
enteritis associated with coccidiosis in dogs.
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Albon is a low-dosage, rapidly absorbed, long-acting sulfonamide,
effective for the treatment of a wide
range of bacterial infections commonly encountered in dogs and cats.
Sulfadimethoxine is a white, almost tasteless and odorless compound.
Chemically, it is N -(2,6-
dimethoxy-4-pyrimidinyl) sulfanilamide. The structural formula is:
CLINICAL PHARMACOLOGY
Sulfadimethoxine has been demonstrated clinically or in the laboratory
to be effective against a variety
of organisms, such as streptococci, klebsiella, proteus, shigella,
staphylococci, escherichia, and
salmonella.
These organisms have been demonstrated in respiratory, genitourinary,
enteric, and soft
tissue infections of dogs and cats.
The systemic sulfonamides which include sulfadimethoxine are
bacteriostatic agents. Sulfonamides
competitively inhibit bacterial synthesis of folic acid
(pteroylglutamic acid) from para-aminobenzoic
acid. Mammalian cells are capable of utilizing folic acid in the
presence of sulfonamides.
The tissue distribution of sulfadimethoxine, as with all sulfonamides,
is a function of plasma levels,
degree of plasma protein binding, and subsequent passive distribution
in the tissues of the lipid-soluble
un-ionized form. The relative amounts are determined by both its pKa
and by the pH of each tissue.
Therefore, levels tend to be higher in less acid tissue and body
fluids or those diseased tissues having
®
1
1,2
2
high concentrations of leucocytes.
In the dog, sulfadimethoxine is not acetylated as in most other
animals, and it is excreted predominantly
as the unchanged drug.
Sulfadimethoxine has a relatively high solubility at the pH normally
occurring
in the kid