TRIAMCINOLONE ACETONIDE cream

Pays: États-Unis

Langue: anglais

Source: NLM (National Library of Medicine)

Ingrédients actifs:

TRIAMCINOLONE ACETONIDE (UNII: F446C597KA) (TRIAMCINOLONE ACETONIDE - UNII:F446C597KA)

Disponible depuis:

Renaissance Pharma, Inc.

DCI (Dénomination commune internationale):

TRIAMCINOLONE ACETONIDE

Composition:

TRIAMCINOLONE ACETONIDE 0.25 mg in 1 g

Type d'ordonnance:

PRESCRIPTION DRUG

Statut de autorisation:

New Drug Application

Résumé des caractéristiques du produit

TRIAMCINOLONE ACETONIDE- TRIAMCINOLONE ACETONIDE CREAM
RENAISSANCE PHARMA, INC.
----------
TRIAMCINOLONE ACETONIDE CREAM USP
TRIAMCINOLONE ACETONIDE CREAM USP,
0.025%, 0.1%
TRIAMCINOLONE ACETONIDE - TRIAMCINOLONE ACETONIDE CREAM
RENAISSANCE PHARMA, INC.,
----------
TRIAMCINOLONE ACETONIDE CREAM USP,
0.025%, 0.1% RX ONLY
DESCRIPTION:
Triamcinolone Acetonide Cream USP contains Triamcinolone Acetonide
[Pregna-1,4-diene-3,20-dione,
9-fluoro-11,21-
dihydroxy-16,17-[(1-methylethylidene)bis-(oxy)]-,(11β,16α)-],with
the empirical
formula C
H FO and molecular weight 434.50. CAS 76-25-5.
Triamcinolone Acetonide Cream USP, 0.025% contains: 0.25 mg of
Triamcinolone Acetonide per gram
in a base containing Propylene Glycol, Cetearyl Alcohol/Ceteareth-20,
White Petrolatum, Sorbitol
Solution, Simethicone Emulsion and Purified Water.
Triamcinolone Acetonide Cream USP, 0.1% contains: 1 mg of
Triamcinolone Acetonide per gram in a
base containing Propylene Glycol, Cetearyl Alcohol/Ceteareth-20, White
Petrolatum, Sorbitol Solution,
Simethicone Emulsion and Purified Water.
CLINICAL PHARMACOLOGY:
Topical corticosteroids share anti-inflammatory, anti-pruritic and
vasoconstrictive actions. The
mechanism of anti- inflammatory activity of the topical
corticosteroids is unclear. Various laboratory
methods, including vasoconstrictor assays, are used to compare and
predict potencies and/or clinical
efficacies of the topical corticosteroids. There is some evidence to
suggest that a recognizable
correlation exists between vasoconstrictor potency and therapeutic
efficacy in man.
PHARMACOKINETICS :
The extent of percutaneous absorption of topical corticosteroids is
determined by many factors
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31
6
including the vehicle, the integrity of the epidermal barrier, and the
use of occlusive dressings. Topical
corticosteroids can be absorbed from normal intact skin. Inflammation
and/or other disease processes in
the skin increase percutaneous absorption. Occlusive dressings
substantially increase the percutaneous
absorption of topical corticosteroids