Pays: Canada
Langue: anglais
Source: Health Canada
ZINC (ZINC SULFATE); COPPER (CUPRIC SULFATE); MANGANESE (MANGANESE SULFATE); CHROMIUM (CHROMIC CHLORIDE); SELENIUM (SELENIOUS ACID); IODIDE (SODIUM IODIDE)
PHARMACEUTICAL PARTNERS OF CANADA INC
B05XA30
COMBINATIONS OF ELECTROLYTES
5MG; 1MG; 0.5MG; 10MCG; 60MCG; 75MCG
SOLUTION
ZINC (ZINC SULFATE) 5MG; COPPER (CUPRIC SULFATE) 1MG; MANGANESE (MANGANESE SULFATE) 0.5MG; CHROMIUM (CHROMIC CHLORIDE) 10MCG; SELENIUM (SELENIOUS ACID) 60MCG; IODIDE (SODIUM IODIDE) 75MCG
INTRAVENOUS
10ML
Ethical
REPLACEMENT PREPARATIONS
Active ingredient group (AIG) number: 0623891001; AHFS:
CANCELLED POST MARKET
2008-02-15
PRODUCT MONOGRAPH M.T.E.® - 6 CONCENTRATED _Multi-Trace Element_ Pharmaceutical Partners of Canada Inc. Date of Preparation: 45 Vogell Road, Suite 200 January 15, 2008 Richmond Hill, ON L4B 3P6 Control No.: 119202 1 NAME OF DRUG M.T.E.®-6 CONCENTRATED THERAPEUTIC CLASSIFICATION Multi-Trace Element ACTIONS AND CLINICAL PHARMACOLOGY ZINC Zinc is an essential nutritional element that plays a key role as a component of numerous metalloenzymes such as carbonic anhydrase, alkaline phosphatase, lactic dehydrogenase and carboxypeptidase. At least one zinc metalloenzyme has been identified in each of the six major categories of enzymes; i.e., oxidoreductase, transferase, hydrolase, lyase, isomerase and ligase. Zinc is also necessary for the synthesis of RNA and DNA, making it important in the normal growth and development process. Zinc helps maintain normal skin hydration and the senses of taste and smell and facilitates wound healing. Zinc resides in muscle, bone, skin, kidney, liver, pancreas, retina, prostate and particularly in red and white blood cells. Calculations from data indicate that 75 to 88% of the total zinc of normal blood is contained in red cells (primarily in the zinc metalloenzyme carbonic anhydrase), 12 to 22% in the plasma and 3% in the leukocytes. Normal plasma levels of zinc vary from approximately 88 to 122 μg/100 ml. Practically all zinc in serum is protein bound including plasma albumin, α2-macroglobulin and some plasma amino acids including histidine, cysteine, threonine, glycine and asparagine. Infection influences the uptake of zinc by the liver and reduces plasma concentration. This process is stimulated by leukocyte endogenous mediator (LEM). Absorption of zinc occurs mainly in the small intestine, predominantly in the duodenum. The primary excretory pathway for zinc is the faeces and pancreatic secretion. The largest component comes from direct transfer of zinc through the intestinal wall. Several researchers showed that diarrhea, stomal and fistula losses were major sites of abnormal l Lire le document complet