METHSCOPOLAMINE bromide tablet

Pays: États-Unis

Langue: anglais

Source: NLM (National Library of Medicine)

Ingrédients actifs:

METHSCOPOLAMINE BROMIDE (UNII: RTN51LK7WL) (METHSCOPOLAMINE - UNII:VDR09VTQ8U)

Disponible depuis:

Golden State Medical Supply, Inc.

DCI (Dénomination commune internationale):

METHSCOPOLAMINE BROMIDE

Composition:

METHSCOPOLAMINE BROMIDE 5 mg

Type d'ordonnance:

PRESCRIPTION DRUG

Statut de autorisation:

Abbreviated New Drug Application

Résumé des caractéristiques du produit

METHSCOPOLAMINE- METHSCOPOLAMINE BROMIDE TABLET
GOLDEN STATE MEDICAL SUPPLY, INC.
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METHSCOPOLAMINE BROMIDE TABLETS USP, 2.5 MG METHSCOPOLAMINE BROMIDE
TABLETS USP, 5 MG
RX ONLY
DESCRIPTION
Methscopolamine Bromide Tablets USP, 2.5 mg and 5mg contain
methscopolamine bromide, an
anticholinergic, which occurs as white crystals, or as a white
odorless crystalline powder.
Methscopolamine bromide melts at about 225°C with decomposition. The
drug is freely soluble in
water, slightly soluble in alcohol, and insoluble in acetone and in
chloroform.
The chemical name for methscopolamine bromide is
3-Oxa-9-azoniatricyclo [3.3.1.02,1ronane, 7-(3-
hydroxy-1-000-2-phenyl-propoxy)-9, 9-dimethyl-, bromide, [7(5)-(1.,
26, 46, 5., 76) ]-and the
molecular weight is 398.30.
The structural formula is represented below:
METHSCOPOLAMINE BROMIDE TABLETS USP, 2.5 MG for oral administration
contain 2.5 mg of
methscopolamine bromide.
METHSCOPOLAMINE BROMIDE TABLETS USP, 5 MG for oral administration
contain 5mg of
methscopolamine bromide.
Inactive ingredients: microcrystalline cellulose, pregelatinized
starch, magnesium stearate.
Contains no lactose.
CLINICAL PHARMACOLOGY
Methscopolamine bromide is an anticholinergic agent which possesses
most of the pharmacological
actions of that drug class. These include reduction in volume and
total acid content gastric secretion,
inhibition of gastrointestinal motility, inhibition of salivary
excretion, dilation of the pupil and inhibition
of accommodation with resulting blurring of vision. Large doses may
result in tachycardia.
PHARMACOKINETICS
Methscopolamine bromide is quaternary ammonium derivative of
scopolamine. As a class, these agents
are poorly and unreliably absorbed.
Total absorption of quaternary ammonium derivatives of the
alkaloids is 10-25%. Rate of absorption is not available. Quaternary
ammonium salts have limited
absorption from intact skin, and conjunctival penetration is poor.
Little is known of the fate and
excretion of most of these agents .
Following oral administration,