LIOTHYRONINE SODIUM tablet

Pays: États-Unis

Langue: anglais

Source: NLM (National Library of Medicine)

Ingrédients actifs:

LIOTHYRONINE SODIUM (UNII: GCA9VV7D2N) (LIOTHYRONINE - UNII:06LU7C9H1V)

Disponible depuis:

Northwind Pharmaceuticals

DCI (Dénomination commune internationale):

LIOTHYRONINE SODIUM

Composition:

LIOTHYRONINE 50 ug

Mode d'administration:

ORAL

Type d'ordonnance:

PRESCRIPTION DRUG

indications thérapeutiques:

Thyroid hormone drugs are indicated: As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema and ordinary hypothyroidism in patients of any age (pediatric patients, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism (see WARNINGS). As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto’s) and multinodular goiter. As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland aut

Statut de autorisation:

Abbreviated New Drug Application

Résumé des caractéristiques du produit

LIOTHYRONINE SODIUM- LIOTHYRONINE SODIUM TABLET
NORTHWIND PHARMACEUTICALS
----------
LIOTHYRONINE SODIUM
BOXED WARNING
Drugs with thyroid hormone activity, alone or together with other
therapeutic agents, have been
used for the treatment of obesity. In euthyroid patients, doses within
the range of daily hormonal
requirements are ineffective for weight reduction. Larger doses may
produce serious or even
life-threatening manifestations of toxicity, particularly when given
in association with
sympathomimetic amines such as those used for their anorectic effects.
DESCRIPTION
Thyroid hormone drugs are natural or synthetic preparations containing
tetraiodothyronine (T4,
levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or
both. T4 and T3 are produced
in the human thyroid gland by the iodination and coupling of the amino
acid tyrosine. T4 contains four
iodine atoms and is formed by the coupling of two molecules of
diiodotyrosine (DIT). T3 contains
three atoms of iodine and is formed by the coupling of one molecule of
DIT with one molecule of
monoiodotyrosine (MIT). Both hormones are stored in the thyroid
colloid as thyroglobulin.
Thyroid hormone preparations belong to two categories: (1) natural
hormonal preparations derived from
animal thyroid, and (2) synthetic preparations. Natural preparations
include desiccated thyroid and
thyroglobulin. Desiccated thyroid is derived from domesticated animals
that are used for food by man
(either beef or hog thyroid), and thyroglobulin is derived from
thyroid glands of the hog. The United
States Pharmacopeia (USP) has standardized the total iodine content of
natural preparations. Thyroid
USP contains not less than (NLT) 0.17 percent and not more than (NMT)
0.23 percent iodine, and
thyroglobulin contains not less than (NLT) 0.7 percent of organically
bound iodine. Iodine content is
only an indirect indicator of true hormonal biologic activity.
Liothyronine sodium tablets contain liothyronine (L-triiodothyronine
or LT3), a synthetic form of a
natural thyroid hormone