LAMOTRIGINE GENERIC HEALTH lamotrigine 50mg dispersible tablet blister pack

Pays: Australie

Langue: anglais

Source: Department of Health (Therapeutic Goods Administration)

Ingrédients actifs:

Lamotrigine

Disponible depuis:

Torrent Australasia Pty Ltd

DCI (Dénomination commune internationale):

Lamotrigine

Notice patient

1406 Lamotrigine generic health CMI v3
1
CONSUMER MEDICINE INFORMATION
LAMOTRIGINE
GENERIC HEALTH
There are reports of severe, potentially life-threatening rashes
associated with Lamotrigine generic health
treatment, particularly in children. Lamotrigine generic health should
be discontinued at the first sign of
rash unless the rash is clearly not drug related.
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Lamotrigine generic
health. It does not contain all of the
available information. It does not take
the place of talking to your doctor or
pharmacist.
All medicines have risks and benefits.
Your doctor has weighed the risk of you
taking Lamotrigine generic health
against the benefits they expect it will
have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR DOCTOR
OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT LAMOTRIGINE GENERIC
HEALTH IS USED FOR
Lamotrigine generic health contain
lamotrigine as the active ingredient in
and belongs to a group of medicines
called "anti-epileptic drugs"
Anti-epileptic drugs such as Lamotrigine
generic health are used to treat several
conditions, including epilepsy.
Lamotrigine generic health is used for
the treatment of epilepsy in patient over
2 years of age. In general, it is initially
used in addition to other medicines for
the treatment of epilepsy including
partial
or generalised seizures and
Lennox-Gastaut Syndrome.
It is thought that Lamotrigine generic
health works by changing the levels of
some chemicals associated with
seizures.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY LAMOTRIGINE
GENERIC HEALTH HAS BEEN PRESCRIBED
FOR YOU.
Your doctor may have prescribed it for
another reason.
This medicine is only available with a
doctor’s prescription.
It is not addictive.
BEFORE YOU TAKE
LAMOTRIGINE GENERIC HEALTH
_WHEN YOU MUST NOT TAKE IT _
_ _

DO NOT TAKE LAMOTRIGINE GENERIC
HEALTH IF YOU HAVE EVER HAD AN
ALLERGIC REACTION TO:

lamotrigine

any of the ingredients liste

Résumé des caractéristiques du produit

1404 LAMOTRIGINE GENRIC HEALTH PI_v5 Ref: 05/2013
Page 1 of 29
PRODUCT INFORMATION
LAMOTRIGINE GENERIC HEALTH
Lamotrigine Dispersible Tablets 25/50/100/200 mg
Severe, potentially life threatening rashes have been reported in
association with the
use of lamotrigine, particularly in children. Accordingly, lamotrigine
should be
discontinued at the first sign of rash unless the rash is clearly not
drug related. (See
DOSAGE AND ADMINISTRATION)
NAME OF THE MEDICINE
Chemical
name:
3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
(CAS:
84057-84-1),
and the chemical structure is:
DESCRIPTION
Lamotrigine is a substituted asymmetric triazine.
The pKa of lamotrigine at 25°C is 5.7. It is a white to pale cream
coloured powder. It is
slightly soluble in ethanol and chloroform and very slightly soluble
in water.
The active ingredient is lamotrigine. The tablet also contains
_c_rospovidone, povidone K-
30,
mannitol,
microcrystalline
cellulose,
colloidal
anhydrous
silica,
aspartame,
croscarmellose sodium, magnesium stearate and Trusil blackcurrant
S4468 (ARTG NO.
11995)
PHARMACOLOGY
The precise mechanism of the anticonvulsant action of lamotrigine is
not certain. The
results of neurochemical and electrophysiological studies with various
_ in vitro_ and _ in _
_vivo_ preparations indicate that lamotrigine can inhibit voltage
gated sodium channels
and
reduce
the
release
of
glutamate,
an
excitatory
amino
acid
implicated
in
the
pathophysiology of epilepsy. It is possible that these effects
underlie inhibition of the
sustained repetitive firing of action potentials characteristic of
neurons in epileptic foci,
thereby limiting the spread of seizures.
1404 LAMOTRIGINE GENRIC HEALTH PI_v5 Ref: 05/2013
Page 2 of 29
In tests designed to evaluate the CNS effects of drugs, the results
obtained using doses
of 240 mg lamotrigine administered to healthy adult volunteers did not
differ from
placebo, whereas both 1000 mg phenytoin and 10 mg diazepam each
significantly
impaired fine visual motor coordination and eye movements, increased
body swa