Pays: Afrique du Sud
Langue: anglais
Source: South African Health Products Regulatory Authority (SAHPRA)
Hexal
INDICATIONS [/za_1233.html#1] [/za_1233.html#1] [/za_1233.html#1] CONTRA-INDICATIONS [/za_1233.html#1] [/za_1233.html#1] DOSAGE [/za_1233.html#1] [/za_1233.html#1] SIDE-EFFECTS [/za_1233.html#1] [/za_1233.html#1] [/za_1233.html#1] PREGNANCY [/za_1233.html#1] [/za_1233.html#1] OVERDOSE [/za_1233.html#1] IDENTIFICATION [/za_1233.html#1] [/za_1233.html#1] PATIENT INFORMATION HEXAL-LISINOPRIL™ 5 TABLETS HEXAL-LISINOPRIL™ 10 TABLETS HEXAL-LISINOPRIL™ 20 TABLETS SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): HEXAL-LISINOPRIL™ 5 TABLETS HEXAL-LISINOPRIL™ 10 TABLETS HEXAL-LISINOPRIL™ 20 TABLETS COMPOSITION Each HEXAL-LISINOPRIL 5 tablet contains 5 mg LISINOPRIL as the dihydrate. Each HEXAL-LISNOPRIL 10 tablet contains 10 mg lisinopril as the dihydrate. Each HEXAL-LISINOPRIL 20 tablet contains 20 mg lisinopril as the dihydrate. PHARMACOLOGICAL CLASSIFICATION A.7.1.3 Other hypotensives PHARMACOLOGICAL ACTION Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of angiotensin II which results in decreased vasopressor activity and reduced aldosterone secretion. The latter decrease may result in an increase in serum potassium concentration. While the mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, lisinopril is also antihypertensive in patients with low-renin hypertension. ACE is identical to kininase II, an enzyme that degrades bradykinin. Whether increased levels of bradykinin, a potent vasodilatory peptide, pl Lire le document complet