BAYTRIL Comprimé

Pays: Canada

Langue: français

Source: Health Canada

Ingrédients actifs:

Enrofloxacine

Disponible depuis:

ELANCO CANADA LIMITED

Dosage:

22.7MG

forme pharmaceutique:

Comprimé

Composition:

Enrofloxacine 22.7MG

Mode d'administration:

Orale

Unités en paquet:

100/500

Type d'ordonnance:

Prescription

Groupe thérapeutique:

Chats; Chiens

Descriptif du produit:

Numéro de groupe d'ingrédients actifs (GIA) :0121066002

Statut de autorisation:

APPROUVÉ

Date de l'autorisation:

2021-01-06

Notice patient

Pr
Baytril 22.7 mg and 68 mg Package Insert
04Jan2021
PR
BAYTRIL
1
22.7 MG AND 68 MG PACKAGE INSERT
2
DIN 02169444 - 22.7 mg
3
DIN 02169452 - 68 mg
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_ _
5
_PR _BAYTRIL_ _
6
(ENROFLOXACIN)
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ANTIMICROBIAL TABLETS
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9
FOR VETERINARY USE ONLY
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DESCRIPTION: Enrofloxacin is a synthetic chemo-therapeutic agent from
the class of
12
the quinolone carboxylic acid derivatives. It has antibacterial
activity against a broad
13
spectrum of Gram negative and Gram positive bacteria. (See Table 1).
It is rapidly
14
absorbed from the digestive tract, penetrating into all measured body
tissues and fluids.
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(See Table 2). Tablets are available in three sizes (22.7, 68.0 mg
enrofloxacin).
16
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CHEMICAL NOMENCLATURE:
1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-
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dihydro-4-oxo-3-quinolinecarboxylic acid.
19
20
ACTIONS:
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MICROBIOLOGY: Enrofloxacin, a 4-fluoroquinolone compound, is
bactericidal with activity
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against a broad spectrum of both Gram negative and Gram positive
bacteria.
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Fluoroquinolones elicit their bactericidal properties through
interactions with two
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intercellular enzymes - DNA gyrase (DNA topoisomerase II) and DNA
topoisomerase
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IV - which are essential for bacterial DNA transcription, synthesis
and replication. It is
26
believed that fluoroquinolones actively bind with DNA:ENZYME complexes
and thereby
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inhibit the essential processes catalyzed by the enzymes (DNA
supercoiling and
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chromosomal decatenation)
1
. The ultimate outcome of fluoroquinolone intervention is
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DNA fragmentation and bacterial cell death.
2,3
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31
Enrofloxacin minimum inhibitory concentrations (MICs) were determined
for canine and
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feline bacterial isolates originating from natural infections of the
dermal, gastrointestinal,
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respiratory and urinary systems. Seven hundred and thirty eight (738)
isolates were
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collected from 14 different diagnostic laboratories located throughout
the United States.
35
Bacterial identity was confirmed by colony morphology, Gram stain and
biochemical
36
testing; for mycoplas