Pays: Malaisie
Langue: anglais
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ERYTHROMYCIN ETHYLSUCCINATE
KOTRA PHARMA (M) SDN. BHD.
ERYTHROMYCIN ETHYLSUCCINATE
60 ml; 100 ml
KOTRA PHARMA (M) SDN. BHD.
AXCEL ERYTHROMYCIN ES-400 SUSPENSION Erythromycin (400mg/5ml) 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ WHAT IS IN THIS LEAFLET 1. What Axcel Erythromycin ES- 400 Suspension is used for. 2. How Axcel Erythromycin ES- 400 Suspension works. 3. Before you use Axcel Erythromycin ES-400 Suspension. 4. How to use Axcel Erythromycin ES-400 Suspension. 5. While you are using it. 6. Side effects. 7. Storage and disposal of Axcel Erythromycin ES-400 Suspension. 8. Product description. 9. Manufacturer and Product Registration Holder. 10. Date of revision. WHAT AXCEL ERYTHROMYCIN ES-400 SUSPENSION IS USED FOR Axcel Erythromycin ES-400 Suspension is indicated in the treatment of infections caused by susceptible organisms in the diseases listed below: upper and lower respiratory tract infections, pertussis _(whooping cough)_, skin and soft tissue infections, otitis media, erythrasma (skin disease), listeriosis, diphtheria, primary syphilis (sexually transmitted infection) and prophylaxis of endocarditis (infection of the heart). HOW AXCEL ERYTHROMYCIN ES-400 SUSPENSION WORKS Erythromycin is an antibiotic that belongs to the group of medicines called macrolides. These medicines work by killing or stopping the growth of bacteria, which cause infections. _ _ BEFORE YOU USE AXCEL ERYTHROMYCIN ES-400 SUSPENSION _-When you must not use it _ Do not take Axcel Erythromycin ES- 400 Suspension if: You have ever had an allergic reaction to medicines containing erythromycin or to other antibiotics from the macrolide family. Some of the symptoms of an allergic reaction may include rash, itching or hives, swelling of face, lips, tongue or other parts of the body, shortness of breath, wheezing or difficulty in breathing. You are allergic to any of the ingredients listed at the end of this leaflet. You have liver disease or liver impairment. _ _ _-Before you start to use it _ Tell your doctor if: you are allergic to any medicines. you have impaired liver function. you have history of arrhythmias. you suf Lire le document complet
ERYTHROMYCIN ES-400 COMPOSITION: Each 5ml contains Erythromycin Ethylsuccinate equivalent to Erythromycin 400mg PRESENTATION: White to off white homogeneous suspension with banana flavor when reconstituted. INDICATIONS: Indicated in the treatment of infections caused by susceptible strains of designated organisms in the diseases listed below: upper and lower respiratory tract infections that caused by _Streptococcus _ _pyogenes_ and _Streptococcus _ _pneumoniae_. Pertussis (whooping cough) caused by _ Bordetella pertussis_. Skin and soft tissue infections caused by _Streptococcus _ _pyogenes_ and _Streptococcus _ _aureus_. Otitis media, erythrasma, listeriosis, diphteria, primary syphilis in patients allergy to penicillin, propyhlaxis of endocarditis. PHARMACOLOGY: _Mechanism of Action:_ Erythromycin and other macrolides bind reversibly to the 50S subunit of the ribosome, resulting in blockage of the transpeptidation or translocation reactions, inhibition of protein synthesis, and hence inhibition of cell growth. Its action is predominantly bacteriostatic, but high concentrations are slowly bactericidal against the more sensitive strains. Because of the ready penetration of macrolides into white blood cells and macrophages there has been some interest in their potential synergy with host defence mechanism in vivo. Its actions are increased at moderately alkaline pH (up to about 8.5), particularly in Gram-negative species, probably because of the improved cellular penetration of the nonionised form of the drug. Erythromycin has a broad spectrum activity. The pathogenic organisms which are usually sensitive to Erythromycin include: a) Gram-positive cocci: _Streptococcus _ _pneumoniae, _ _Streptococcus _ _pyogenes. _ _Staphylococcus aureus._ b) Gram-positive organisms: _Bacillus anthracis_, _Corynebacterium diphtheriae_ etc. c) Gram-negative cocci: _Neisseria meningitidis,_ _Neisseria gonnorrhoeae, Moraxella catarrhalis._ d) Gram-negative organisms: _ Bordetella spp., _ _Pasteurella, Haemophilus ducreyi_. Among the Lire le document complet