Pays: États-Unis
Langue: anglais
Source: NLM (National Library of Medicine)
ACYCLOVIR (UNII: X4HES1O11F) (ACYCLOVIR - UNII:X4HES1O11F)
Atlantic Biologicals Corps
ACYCLOVIR
ACYCLOVIR 200 mg in 5 mL
ORAL
PRESCRIPTION DRUG
Acyclovir oral suspension, USP is indicated for the acute treatment of herpes zoster (shingles). Acyclovir oral suspension, USP is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes. Acyclovir oral suspension, USP is indicated for the treatment of chickenpox (varicella). Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.
NDC:17856-0082-1 in a CUP of 5 SUSPENSIONS NDC:17856-0082-5 in a CUP of 5 SUSPENSIONS
Abbreviated New Drug Application
ACYCLOVIR- ACYCLOVIR SUSPENSION ATLANTIC BIOLOGICALS CORPS ---------- ACYCLOVIR ORAL SUSPENSION, USP DESCRIPTION Acyclovir is a synthetic nucleoside analogue active against herpesviruses. Each teaspoonful (5 mL) of acyclovir oral suspension, USP, for oral administration, contains 200 mg of acyclovir and the inactive ingredients artificial banana flavor, carboxymethylcellulose sodium, glycerin, methylparaben 0.1% (added as a preservative), microcrystalline cellulose, propylparaben 0.02% (added as a preservative), purified water, and sorbitol. Acyclovir is a white, crystalline powder with the molecular formula C H N O and a molecular weight of 225. The maximum solubility in water at 37°C is 2.5 mg/mL. The pka’s of acyclovir are 2.27 and 9.25. The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]- 6H-purin-6- one; it has the following structural formula: VIROLOGY: Mechanism of Antiviral Action: Acyclovir is a synthetic purine nucleoside analogue with and inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). _in vitroin vivo_ The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. , acyclovir triphosphate stops replication of herpes viral DNA. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared with VZV is due to its more efficient phosphorylation by the viral TK. _In vitro_ Antiviral Activities: The quantitative relationship between the susceptibility of herpes viruses to antivirals and the clinical response to t Lire le document complet