Maa: Australia
Kieli: englanti
Lähde: Department of Health (Therapeutic Goods Administration)
Sodium valproate
Sanofi-Aventis Australia Pty Ltd
Sodium valproate
_ _ Page 1 valproate-winthrop-ccdsv21-piv13-07dec16 PRODUCT INFORMATION VALPROATE WINTHROP ® NAME OF THE MEDICINE AUSTRALIAN APPROVED NAME Sodium valproate CHEMICAL NAME Sodium di-n-propylacetic acid CHEMICAL STRUCTURE CAS REGISTRY NUMBER 1069-66-5 DESCRIPTION _Active_: Sodium valproate. Sodium valproate is a white, odourless, crystalline powder with a saline taste. It is highly soluble in water and alcohol. Its molecular weight is 166. It is quite dissimilar to other established anticonvulsants such as barbiturates, hydantoins, succinamides, oxazolidinediones and acetylureas in that it has no nitrogen or aromatic moiety. _Inactive_: Crushable: includes maize starch, kaolin, silicon dioxide and magnesium stearate. Enteric-Coated: includes povidone, purified talc, magnesium stearate, calcium silicate, citric acid monohydrate, macrogol 6000, hypromellose, hyprolose, polyvinyl acetate phthalate, diethyl phthalate, stearic acid, amaranth aluminium lake, indigo carmine aluminium lake, titanium dioxide. Sugar-Free Liquid: includes hyetellose, saccharin sodium, sorbitol solution (70%) (non- crystallising), citric acid, brilliant scarlet 4R, purified water, flavour imitation cherry 17.40.0740, sodium methyl hydroxybenzoate and sodium propyl hydroxybenzoate. Syrup: includes sucrose, sorbitol, saccharin sodium, brilliant scarlet 4R, purified water, flavour imitation cherry 17.40.0740, sodium methyl hydroxybenzoate and sodium propyl hydroxybenzoate. PHARMACOLOGY CLASS: Anticonvulsant, antipsychotic. SITE AND MODE OF ACTION: The mode of action of Valproate Winthrop has not been fully established. Its anticonvulsant effect is attributed to the blockade of voltage dependent Na + channels and increased brain levels of -aminobutyric acid (GABA). The GABA-ergic effect is also believed to possibly contribute towards the antimanic properties of sodium valproate. In animals, Valproate Winthrop raises cerebral and cerebellar levels of the inhibitory synaptic transmitter, GABA, possibly by inhibiting GABA degradative enzymes, suc Lue koko asiakirja