Maa: Yhdysvallat
Kieli: englanti
Lähde: NLM (National Library of Medicine)
tiletamine hydrochloride (UNII: 99TAQ2QWJI) (tiletamine - UNII:2YFC543249), zolazepam hydrochloride (UNII: 45SJ093Q1N) (zolazepam - UNII:G1R474U58U)
Putney, Inc.
tiletamine hydrochloride
tiletamine 50 mg in 1 mL
INTRAMUSCULAR
PRESCRIPTION
Tiletamine-Zolazepam is indicated in cats for restraint or for anesthesia combined with muscle relaxation and in dogs for restraint and minor procedures of short duration (30 min. avg.) requiring mild to moderate analgesia. Minor surgery is considered to be laceration repair, draining of abscesses, castrations and other procedures requiring mild to moderate analgesia. (See Dogs under ADMINISTRATION AND DOSAGE.) The use of Tiletamine-Zolazepam is contraindicated in dogs and cats with pancreatic disease. Tiletamine-Zolazepam is excreted predominantly by the kidneys. Preexistent renal pathology or impairment of renal function may be expected to result in prolonged duration of anesthesia. Tiletamine-Zolazepam should not be used in dogs and cats with severe cardiac or pulmonary dysfunction. Because the teratogenic potential of Tiletamine-Zolazepam is unknown, it should not be used in pregnant bitches or queens at any stage of pregnancy. Also, a study has shown that tiletamine HCl and zolazepam HCl crosses the plac
Tiletamine-Zolazepam (tiletamine HCl and zolazepam HCl) is available in individual vials of 5 mL solution when reconstituted. The addition of 5 mL diluent produces a solution containing the equivalent of 50 mg tiletamine base, 50 mg zolazepam base and 57.7 mg mannitol per milliliter. NDC 26637-131-05: 5 mL vial – 100 mg/mL (when reconstituted). Store at controlled room temperature 68-77°F (20-25°C).
Abbreviated New Animal Drug Application
TILETAMINE-ZOLAZEPAM- TILETAMINE HYDROCHLORIDE AND ZOLAZEPAM HYDROCHLORIDE INJECTION, POWDER, FOR SOLUTION PUTNEY, INC. ---------- TILETAMINE-ZOLAZEPAM (TILETAMINE HCL AND ZOLAZEPAM HCL) CIII FOR INTRAMUSCULAR USE IN DOGS AND CATS ONLY ANADA# 200-557, APPROVED BY FDA CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Tiletamine-Zolazepam (tiletamine HCl and zolazepam HCl) is a nonnarcotic, nonbarbiturate, injectable anesthetic agent for dogs and cats. Chemically, Tiletamine-Zolazepam is a combination of equal parts by weight of base of tiletamine hydrochloride (2-[ethylamino]-2- [2-thienyl]-cyclohexanone hydrochloride), an arylaminocycloalkanone dissociative anesthetic, and zolazepam hydrochloride (4-[o- fluorophenyl]-6,8-dihydro-1,3,8- trimethylpyrazolo [3, 4-e] [1,4] diazepin-7 [1H]- 1-hydrochloride), a non- phenothiazine diazepinone having minor tranquilizing properties. The product is supplied sterile in vials. The addition of 5 mL diluent produces a solution containing the equivalent of 50 mg tiletamine base, 50 mg zolazepam base and 57.7 mg mannitol per milliliter. This solution has a pH of 2 to 3.5 and is recommended for deep intramuscular injection. ACTIONS Tiletamine-Zolazepam is a rapid-acting anesthetic combination of tiletamine hydrochloride and zolazepam hydrochloride. Tiletamine hydrochloride is a dissociative anesthetic agent whose pharmacologic action is characterized by profound analgesia, normal pharyngeal-laryngeal reflexes and cataleptoid anesthesia. The anesthetic state produced does not fit into the conventional classification of stages of anesthesia, but instead Tiletamine-Zolazepam produces a state of unconsciousness which has been termed "dissociative" anesthesia in that it appears to selectively interrupt association pathways to the brain before producing somesthetic sensory blockade. Cranial nerve and spinal reflexes remain active; however, these reflexes must not be confused with inadequate anesthesia. Analgesia results from appare Lue koko asiakirja