Maa: Australia
Kieli: englanti
Lähde: Department of Health (Therapeutic Goods Administration)
Ramipril
Generic Health Pty Ltd
Ramipril
Ramipril generichealth CMI v2 Sep2017 Page 1 of 3 CONSUMER MEDICINE INFORMATION RAMIPRIL GENERICHEALTH ramipril What is in this leaflet Ramipril is an angiotensin converting enzyme (ACE) inhibitor. It is a drug which is used to reduce the risk of cardiovascular problems (problems related to the heart and blood vessels) in high risk patients, to lower high blood pressure (hypertension), and to help slow down the progression of kidney disease. What Ramipril generichealth is used for The benefits that you will get from Ramipril generichealth will depend on the reason why your doctor has prescribed it. Please talk to your doctor if you want more information on why it has been prescribed for you. Ramipril generichealth might be prescribed for you: If you have heart or blood vessels disease, have had a heart attack or stroke, or diabetes and one other risk factor, your doctor may decide that Ramipril generichealth is appropriate for you. Ramipril generichealth can reduce your chances of having a heart attack, stroke, or death due to heart disease, by keeping the blood vessel walls and heart muscle healthy. If you have high blood pressure (hypertension). Ramipril generichealth is used to lower high blood pressure by relaxing constricted blood vessels in hypertensive patients. If you have kidney disease. Ramipril generichealth slows down the progression of kidney disease by lowering blood pressure if it is too high, and improving the health of kidney cells. Before you take Ramipril generichealth When not to take it Follow all directions given to you by your doctor or pharmacist carefully. Do not take Ramipril generichealth if you: Have had an allergy to Ramipril generichealth (ramipril), or any of the ingredients in Ramipril generichealth (listed at the end of this leaflet). Have previously taken any other ACE-inhibitor medicine that caused your face, lips, tongue or throat to swell, or made it hard for you to breathe. Have kidney failure (note that your doctor may give Ramipril generichealth because of your kidney probl Lue koko asiakirja
1404 Ramipril Generichealth PI V2 Ref: 02/2014 1 PRODUCT INFORMATION RAMIPRIL GENERICHEALTH CAPSULES NAME OF THE MEDICINE Ramipril DESCRIPTION Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105 ° C and 112 ° C. Ramipril's chemical name is (2_S_,3a_S_,6a_S_)-1-[(_S_)-2-[[(_S_)-l-(ethoxycarbonyl)-3-phenylpropyl] amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid; its structural formula is: Its empiric formula is C 23 H 32 N 2 O 5 , and its molecular weight is 416.5. Ramipril has five chiral centres. It has _S_-configuration in all five asymmetric carbon atoms. CAS NUMBER: 87333-19-5 PHARMACOLOGY MECHANISM OF ACTION Ramipril is a prodrug which, after absorption from the gastrointestinal tract, is hydrolysed in the liver to form the active moiety, ramiprilat. Ramipril and ramiprilat inhibit angiotensin-converting enzyme (ACE) which is identical to KININASE II. This converting enzyme (ACE) is a peptidyl dipeptidase that catalyses the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex, thus 1404 Ramipril Generichealth PI V2 Ref: 02/2014 2 inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. The latter decrease may result in a small increase in serum potassium. KININASE II is one of the enzymes responsible for the degradation of bradykinin, a potent vasodepressor peptide. The inhibition of KININASE II activity by ramipril prevents the degradation of bradykinin thus leading to increased levels of this potent vasodepressor substance. While the mechanism through which ramipril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, ramipril has an antihypertensive effect even in patients with low renin hypertension. Lue koko asiakirja