PROBENECID tablet, film coated

Maa: Yhdysvallat

Kieli: englanti

Lähde: NLM (National Library of Medicine)

Aktiivinen ainesosa:

PROBENECID (UNII: PO572Z7917) (PROBENECID - UNII:PO572Z7917)

Saatavilla:

Carilion Materials Management

INN (Kansainvälinen yleisnimi):

PROBENECID

Koostumus:

PROBENECID 500 mg

Antoreitti:

ORAL

Prescription tyyppi:

PRESCRIPTION DRUG

Käyttöaiheet:

Probenecid tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis. As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given. Hypersensitivity to probenecid. Children under 2 years of age. Not recommended in persons with known blood dyscrasias or uric acid kidney stones. Therapy with probenecid should not be started until an acute gouty attack has subsided.

Tuoteyhteenveto:

NDC:68151-1993-0 in a PACKAGE of 1 TABLET, FILM COATEDS

Valtuutuksen tilan:

Abbreviated New Drug Application

Valmisteyhteenveto

PROBENECID- PROBENECID TABLET, FILM COATED
CARILION MATERIALS MANAGEMENT
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DESCRIPTION
Probenecid is a uricosuric and renal tubular transport blocking agent.
The chemical name for probenecid is 4-[(dipropylamino) sulfonyl]
benzoic acid (molecular weight
285.37). It has the following structural formula:
C H NO S
Probenecid, USP is a white or nearly white, fine, crystalline powder.
Probenecid is soluble in dilute
alkali, in alcohol, in chloroform, and in acetone; it is practically
insoluble in water and in dilute acids.
Each tablet for oral administration contains 500 mg of probenecid and
the following inactive
ingredients: colloidal silicon dioxide, hypromellose, magnesium
stearate, microcrystalline cellulose,
polydextrose, polyethylene glycol, sodium carbonate, sodium lauryl
sulfate, sodium starch glycolate,
cornstarch, titanium dioxide, triacetin, FD&C Yellow #6, D&C Yellow
#10, and FD&C Blue #2.
CLINICAL PHARMACOLOGY
Probenecid is a uricosuric and renal tubular blocking agent. It
inhibits the tubular reabsorption of urate,
thus increasing the urinary excretion of uric acid and decreasing
serum urate levels. Effective
uricosuria reduces the miscible urate pool, retards urate deposition,
and promotes resorption of urate
deposits.
Probenecid inhibits the tubular secretion of penicillin and usually
increases penicillin plasma levels by
any route the antibiotic is given. A 2-fold to 4-fold elevation has
been demonstrated for various
penicillins.
Probenecid also has been reported to inhibit the renal transport of
many other compounds including
aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin,
sodium iodomethamate and related
iodinated organic acids, 17-ketosteroids, pantothenic acid,
phenolsulfonphthalein (PSP), sulfonamides,
and sulfonylureas. See also . Drug Interactions
Probenecid decreases both hepatic and renal excretion of
sulfobromophthalein (BSP). The tubular
reabsorption of phosphorus is inhibited in hypoparathyroid but not in
euparathyroid individuals.
Probenecid does not influence