LIOTHYRONINE SODIUM tablet

Maa: Yhdysvallat

Kieli: englanti

Lähde: NLM (National Library of Medicine)

Aktiivinen ainesosa:

LIOTHYRONINE SODIUM (UNII: GCA9VV7D2N) (LIOTHYRONINE - UNII:06LU7C9H1V)

Saatavilla:

Proficient Rx LP

Antoreitti:

ORAL

Prescription tyyppi:

PRESCRIPTION DRUG

Käyttöaiheet:

Thyroid hormone drugs are indicated: Liothyronine sodium tablets can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef. Thyroid hormone preparations are generally contraindicated in patients with diagnosed but as yet uncorrected adrenal cortical insufficiency, untreated thyrotoxicosis and apparent hypersensitivity to any of their active or extraneous constituents. There is no well-documented evidence from the literature, however, of true allergic or idiosyncratic reactions to thyroid hormone.

Tuoteyhteenveto:

Each 5 mcg tablet contains liothyronine sodium equivalent to 5 mcg of liothyronine. 5 mcg - Round, white to off-white color tablets debossed “Σ” on one side and “18”on the other side. They are available in bottles of 30s (NDC 71205-150-30), 60s (NDC 71205-150-60) and 90s (NDC 71205-150-90). Store between 15° and 30°C (59° and 86°F). Manufactured by: Sigmapharm Laboratories, LLC Bensalem, PA 19020 Repackaged by: Proficient Rx LP Thousand Oaks, CA 91320 OS020-05 REV.0118

Valtuutuksen tilan:

Abbreviated New Drug Application

Valmisteyhteenveto

LIOTHYRONINE SODIUM- LIOTHYRONINE SODIUM TABLET
PROFICIENT RX LP
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LIOTHYRONINE SODIUM TABLETS, USP
Drugs with thyroid hormone activity, alone or together with other
therapeutic
agents, have been used for the treatment of obesity. In euthyroid
patients, doses
within the range of daily hormonal requirements are ineffective for
weight
reduction. Larger doses may produce serious or even life-threatening
manifestations of toxicity, particularly when given in association
with
sympathomimetic amines such as those used for their anorectic effects.
DESCRIPTION
Thyroid hormone drugs are natural or synthetic preparations containing
tetraiodothyronine (T
, levothyroxine) sodium or triiodothyronine (T
, liothyronine)
sodium or both. T
and T
are produced in the human thyroid gland by the iodination
and coupling of the amino acid tyrosine. T
contains four iodine atoms and is formed by
the coupling of two molecules of diiodotyrosine (DIT). T
contains three atoms of iodine
and is formed by the coupling of one molecule of DIT with one molecule
of
monoiodotyrosine (MIT). Both hormones are stored in the thyroid
colloid as
thyroglobulin.
Thyroid hormone preparations belong to two categories: (1) natural
hormonal
preparations derived from animal thyroid, and (2) synthetic
preparations. Natural
preparations include desiccated thyroid and thyroglobulin. Desiccated
thyroid is derived
from domesticated animals that are used for food by man (either beef
or hog thyroid),
and thyroglobulin is derived from thyroid glands of the hog. The
United States
Pharmacopeia (USP) has standardized the total iodine content of
natural preparations.
Thyroid USP contains not less than (NLT) 0.17 percent and not more
than (NMT) 0.23
percent iodine, and thyroglobulin contains not less than (NLT) 0.7
percent of organically
bound iodine. Iodine content is only an indirect indicator of true
hormonal biologic
activity.
Liothyronine sodium tablets contain liothyronine (L-triiodothyronine
or LT
), a synthetic
form of a natural thyroid hormone, and is avail