Maa: Yhdysvallat
Kieli: englanti
Lähde: NLM (National Library of Medicine)
DEXAMETHASONE SODIUM PHOSPHATE (UNII: AI9376Y64P) (DEXAMETHASONE - UNII:7S5I7G3JQL)
Physicians Total Care, Inc.
DEXAMETHASONE SODIUM PHOSPHATE
DEXAMETHASONE SODIUM PHOSPHATE 10 mg in 1 mL
INTRAVENOUS
PRESCRIPTION DRUG
Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance). Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; mineralocorticoid supplementation may be necessary, particularly when synthetic analogs are used). Preoperatively, and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful. Shock unresponsive to conventional therapy if adrenocortical insufficiency exists or is suspected. Congenital adrenal hyperplasia. Nonsuppurative thyroiditis. Hypercalcemia associated with cancer. As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Post-traumatic osteoarthritis. Synovitis of osteoarthritis. Rheumatoid arthritis, including juvenile
Dexamethasone Sodium Phosphate Injection is available as follows: Dexamethasone Sodium Phosphate Equivalent To 10 mL multiple dose vials packaged 10 per shelf carton. 10 mg per mL—For intravenous and intramuscular injection only. Sensitive to heat. Do not autoclave. Protect from freezing. Protect from light. Multiple dose vials—store in carton until contents are used. Store at controlled room temperature 15°–30°C (59°–86°F).
Abbreviated New Drug Application
DEXAMETHASONE SODIUM PHOSPHATE - DEXAMETHASONE INJECTION PHYSICIANS TOTAL CARE, INC. ---------- DEXAMETHASONE SODIUM PHOSPHATE INJECTION, USP DESCRIPTION Dexamethasone sodium phosphate, a synthetic adrenocortical steroid, is a white or slightly yellow, crystalline powder. It is freely soluble in water and is exceedingly hygroscopic. The molecular weight is 516.41. It is designated chemically as 9-fluoro-11ß,17-dihydroxy-16a-methyl-21-(phosphonooxy) pregna-1,4-diene-3,20-dione disodium salt. The empirical formula is C H FNa O P and the structural formula is: Dexamethasone sodium phosphate injection is a sterile solution of dexamethasone sodium phosphate, and is supplied in 10 mg per mL. Dexamethasone sodium phosphate injection 10 mg per mL is a sterile solution for intravenous or intramuscular use only. Each mL contains: Dexamethasone sodium phosphate equivalent to 10 mg dexamethasone phos-phate; sodium citrate anhydrous 10 mg; sodium metabisulfite 1 mg; benzyl alcohol 10 mg; water for injection qs; pH is adjusted with citric acid and/or NaOH if necessary. pH: 7.0–8.5 CLINICAL PHARMACOLOGY Dexamethasone sodium phosphate injection has a rapid onset but short duration of action when compared with less soluble preparations. Because of this, it is suitable for the treatment of acute disorders responsive to adrenocortical steroid therapy. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs, including dexamethasone, are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. At equipotent anti-inflammatory doses, dexamethasone almost completely lacks the sodium-retaining property of hydrocortisone and closely related derivatives of hydrocortisone. INDICATIONS AND USAGE A. BY INTRAVENOUS OR INTRAMUSC Lue koko asiakirja