Maa: Australia
Kieli: englanti
Lähde: Department of Health (Therapeutic Goods Administration)
Indapamide hemihydrate; Perindopril arginine
Servier Laboratories (Australia) Pty Ltd
Medicine Registered
COVERSYL ® PLUS LD 2.5MG/0.625MG; COVERSYL ® PLUS 5MG/1.25MG _perindopril (pronounced per-in-do-pril) and indapamide (pronounced in-dap-a-mide)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about COVERSYL PLUS. It does not contain all the available information about this medicine. Reading this leaflet does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking COVERSYL PLUS against the expected benefits for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT COVERSYL PLUS IS The name of your medicine is COVERSYL PLUS. The medicine contains the active ingredients perindopril arginine and indapamide hemihydrate. Perindopril belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. Indapamide belongs to a group of medicines called chlorosulphamoyl diuretics. WHAT COVERSYL PLUS IS USED FOR YOU HAVE BEEN PRESCRIBED COVERSYL PLUS FOR HIGH BLOOD PRESSURE. COVERSYL PLUS is available only with a doctor's prescription. There is no evidence that COVERSYL PLUS is addictive. _WHY COVERSYL PLUS IS_ _USED FOR HIGH BLOOD_ _PRESSURE_ Everyone has blood pressure. This pressure helps to circulate blood all around the body. Your blood pressure may be different at different times of the day, depending on how busy or stressed you are. You have high blood pressure (also known as hypertension) when your blood pressure stays higher than is needed, even when you are calm and relaxed. If high blood pressure is not treated it can lead to serious health problems. You may feel fine and have no symptoms, but eventually it can cause stroke, heart disease and kidney failure. COVERSYL PLUS helps to lower your blood pressure. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY COVERSYL PLUS HAS BEEN PRESCRIBED FOR YOU. BEFORE YOU TAKE COVERSYL PLUS Lue koko asiakirja
COVERSYL ® PLUS – PRODUCT INFORMATION 1(27) Version 10a PRODUCT INFORMATION NAME OF THE MEDICINE _COVERSYL PLUS 5MG/1.25MG _ Perindopril arginine 5 mg / Indapamide hemihydrate 1.25 mg _COVERSYL PLUS LD 2.5MG/0.625MG _ Perindopril arginine 2.5 mg / Indapamide hemihydrate 0.625 mg Perindopril arginine Perindopril is a dipeptide monoacid monoester with a perhydroindole group and no sulphydryl radical. The drug substance is the arginine salt of perindopril. It has the chemical name, L-arginine (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino] propanoyl] octahydro-1H-indole-2- carboxylate _ _ _CAS Registry Number _: 612548-45-5 _Molecular formula _: C 19 H 32 N 2 O 5 , C 6 H 14 N 4 O 2 _Chemical structure _: , N H H COOH O N H CH 3 C H 3 O O C H 3 N H 2 N H NH COOH NH 2 Indapamide Indapamide is a non-thiazide indole derivative of chlorosulphonamide; chemical name 4-chloro-_N_- [(2_RS_)-2-methyl-2,3-dihydro-1_H_-indol-1-yl]-3-sulphamoylbenzamide hemihydrate. _CAS Registry Number _: 26807-65-8 _Molecular formula _: C 16 H 16 ClN 3 O 3 S, ½ H2O _Chemical structure _: , ½ H 2 O COVERSYL ® PLUS – PRODUCT INFORMATION 2(27) Version 10a DESCRIPTION Active Ingredients Perindopril arginine is a white powder, readily soluble in purified water, slightly soluble in 95% ethanol and practically insoluble in chloroform. Perindopril has five asymmetric centres. The drug is synthesised stereoselectively so that it is a single enantiomer (all S stereochemistry). Indapamide is a white crystalline lipophilic powder, soluble in methanol, ethanol, acetic acid and ethyl acetate, very slightly soluble in ether, chloroform and benzene, and practically insoluble in water. Excipien Lue koko asiakirja