Maa: Yhdysvallat
Kieli: englanti
Lähde: NLM (National Library of Medicine)
POLYSULFATED GLYCOSAMINOGLYCAN (UNII: 268AW7000T) (POLYSULFATED GLYCOSAMINOGLYCAN - UNII:268AW7000T)
American Regent, Inc.
INTRAMUSCULAR
PRESCRIPTION
Adequan® i.m. is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan.
Adequan® i.m. solution, 500 mg/5 mL (100 mg/mL) in a 5 mL single dose glass vial. NDC 10797-995-70 5 mL Single Dose Vials Packaged 7 vials per box AMERICAN REGENT, INC. ANIMAL HEALTH Shirley, NY 11967 (1-888-354-4857) Approved by FDA under NADA #140-901 Made in U.S.A. IN 99501 Rev. 9/2021 MG # 44455
New Animal Drug Application
ADEQUAN I.M.- POLYSULFATED GLYCOSAMINOGLYCAN INJECTION, SOLUTION AMERICAN REGENT, INC. ---------- ADEQUAN I.M. polysulfated glycosaminoglycan SINGLE DOSE Solution 500 mg/5 mL For Intramuscular Use In Horses CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Each 5 milliliters of Adequan i.m. contains 500 mg of Polysulfated Glycosaminoglycan (PSGAG) and Water for Injection q.s. Sodium Hydroxide and/or Hydrochloric Acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity. PHARMACOLOGY: Polysulfated Glycosaminoglycan is chemically similar to the glycosaminoglycans in articular cartilage matrix. PSGAG is a potent proteolytic enzyme inhibitor and diminishes or reverses the pathologic processes of traumatic or degenerative joint disease which result in a net loss of cartilage matrix components. PSGAG improves joint function by reducing synovial fluid protein levels and increasing synovial fluid hyaluronic acid concentration in traumatized equine carpal and hock joints. INDICATIONS: Adequan i.m. is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. DOSAGE AND ADMINISTRATION: The recommended dose of Adequan i.m. in horses is 500 mg every 4 days for 28 days intramuscularly. The injection site must be thoroughly cleansed prior to injection. Do not mix Adequan i.m. with other drugs or solvents. CONTRAINDICATIONS: There are no known contraindications to the use of intramuscular Polysulfated ® ® ® ® ® Glycosaminoglycan. WARNINGS: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children. PRECAUTIONS: The safe use of Adequan i.m. in horses used for breeding purposes, during pregnancy, or in lactating mares has not been evaluated. ANIMAL SAFETY: Toxicity studies were conducted in horses. Doses as high as 2,500 mg were administered intramus Lue koko asiakirja