WINCARDIA Dispersible Tablet

Riik: Malaisia

keel: inglise

Allikas: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Toimeaine:

ASPIRIN; GLYCINE

Saadav alates:

KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.

INN (Rahvusvaheline Nimetus):

ASPIRIN; GLYCINE

Ühikuid pakis:

10 Tablets; 30 Tablets; 100 Tablets; 500 Tablets; 1000 Tablets; 90 Tablets

Valmistatud:

KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.

Infovoldik

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
_ _
WINCARDIA DISPERSIBLE TABLET
Aspirin/Glycine (100mg/45mg)
1
WHAT IS IN THIS LEAFLET
1.
What WINCARDIA is used for
2.
How WINCARDIA works
3.
Before you use WINCARDIA
4.
How to use WINCARDIA
5.
While you are using WINCARDIA
6.
Side effects
7.
Storage and disposal of
WINCARDIA
8.
Product description
9.
Manufactured by and Product
Registration Holder
10.
Date of revision
WHAT WINCARDIA IS USED FOR
WINCARDIA
is
indicated
for
mini
stroke,
secondary
prevention
of
heart
attack,
prevention
against
stroke
and
blood clot.
HOW WINCARDIA WORKS
Aspirin
have
analgesic,
anti-
inflammatory,
and
antipyretic
properties.
Glycine
is
used
to
reduce
gastric irritation.
BEFORE YOU USE WINCARDIA
_- When you must not use it _

Not to be given to children under 16
years of age.
Do not use:

if you are allergic to aspirin or any of
its formulation.

if you ever had the problem of your
blood not clotting properly & gout.

if
you
ever
had
an
ulcer
in
your
stomach or small intestine.

if you are treated with Nonsteroidal
Antiinflammatory Drugs (NSAID).
_ _
_-Before you start to use it_
_Pregnancy and lactation_

Talk to you doctor before taking this
medicine if you are pregnant, might
become pregnant or are breastfeeding.

Should
only
be
taken
if
clearly
needed.

Use
during
the
third
trimester
of
pregnancy should be avoided.

Avoid usage in nursing mother.
_-Taking other medicines _
Inform your doctor or pharmacist before
taking
this
medicine s, including any
that you get without a prescription from
your pharmacy, supermarket or health
food shop.
Some
medicines
and
WINCARDIA
may interfere with each other. They may
be affected by WINCARDIA or may
affect how well it works.
It may interact with:

Anticoagulants (e.g. coumarin,
heparin) - prevent blood clots.

Other platelet aggregation inhibitors
(e.g. ticlopidine, Clopidogrel) -
increased bleeding risk.

Drug product containing cortisone,
Alcohol, other Non-steroidal Anti-
inflammatory Drugs (NSAIDs) &
Sel

Toote omadused

WINCARDIA DISPERSIBLE TABLET
(ASPIRIN 100MG & GLYCINE 45MG)
Each tablet contains:
Aspirin ………………………….. 100 mg
Glycine …………………………… 45mg
DESCRIPTION:
PRODUCT DESCRIPTION
White to off-white, round dispersible tablets with “100’’
embossed on top and “W’’ embossed on bottom. It gives
a cloudy liquid with lemon flavour after dispersion with water.
PHARMACODYNAMICS
Acetylsalicylic acid is an analgesic, anti-inflammatory, antipyretic
and an inhibitor of platelet aggregation. It
prolongs the bleeding time. It inhibits fatty acid cyclo-oxygenase by
acetylation of the active site of the enzyme,
and most of its pharmacological effects are due to inhibition of the
formation of cyclo-oxygenase products
including thromboxanes, prostaglandins and prostacyclin.
Acetylsalicylic acid has an active metabolite (salicylate) which, in
addition to possessing some antiinflammatory
properties in its own right, also has important effects on
respiration, acid-base balance and the stomach. Salicylates
stimulate respiration by a direct effect on the medulla, and at high
concentrations, uncouple oxidative
phosphorylation in muscle, increasing oxygen consumption and carbon
dioxide production. Hyperventilation
causes respiratory alkalosis which is compensated by renal excretion
of bicarbonate.
Glycine is used to reduce gastric irritation
.
PHARMACOKINETICS
_Absorption _
In general, immediate Acetylsalicylic acid is well and completely
absorbed from the gastrointestinal (GI) tract.
Following absorption, Acetylsalicylic acid is hydrolyzed to salicylic
acid with peak plasma levels of salicylic acid
occurring within 1-2 hours of dosing. The rate of absorption from the
GI tract is dependent upon the dosage form,
the presence or absence of food, gastric PH(the presence or absence of
GI antacids or buffering agents), and
other physiologic factors. Enteric coated Acetylsalicylic acid
products are erratically absorbed from the GI tract.
_Metabolism _
Acetylsalicylic acid is rapidly hydrolyzed in the p