TRANQIPAM - 1 TABLET

Riik: Lõuna-Aafrika Vabariik

keel: inglise

Allikas: South African Health Products Regulatory Authority (SAHPRA)

Saadav alates:

Pharmacare Limited û Woodmead

Annus:

See ingredients

Ravimvorm:

TABLET

Koostis:

EACH TABLET CONTAINS LORAZEPAM 1 mg

Volitamisolek:

Registered

Loa andmise kuupäev:

1990-10-02

Toote omadused

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1.3.1.1 PROFESSIONAL INFORMATION FOR MEDICINES FOR HUMAN USE
SCHEDULING STATUS
S5
PROPRIETARY NAME AND DOSAGE FORM
TRANQIPAM - 0,5 (tablet)
TRANQIPAM - 1 (tablet)
TRANQIPAM - 2,5 (tablet)
COMPOSITION
Each tablet of TRANQIPAM - 0,5 contains 0,5 mg of lorazepam
_Excipients: _
Lactose, magnesium stearate, microcrystalline cellulose, polacrilin
potassium.
Contains sugar: Lactose 33,875 mg
Each tablet of TRANQIPAM - 1 contains 1 mg of lorazepam
_Excipients: _
Lactose, magnesium stearate, microcrystalline cellulose, polacrilin
potassium.
Contains sugar: Lactose 67,50 mg
Each tablet of TRANQIPAM - 2,5 contains 2,5 mg of lorazepam
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_Excipients: _
Lactose, magnesium stearate, microcrystalline cellulose, polacrilin
potassium
Contains sugar: Lactose 134,475 mg
CATEGORY AND CLASS
A 2.6 Tranquillizers
PHARMACOLOGICAL ACTION
PHARMACODYNAMIC PROPERTIES
Lorazepam is a benzodiazepine and has anxiolytic properties.
Benzodiazepines presumably
exert their effects by binding to specific receptors at several sites
within the central nervous
system, by potentiating the effects of synaptic or presynaptic
inhibition mediated by gamma-
aminobutyric acid.
PHARMACOKINETIC PROPERTIES
Lorazepam is rapidly absorbed when given orally.
Peak plasma concentrations occur approximately 2 hours following
administration. The half-
life of unconjugated lorazepam in human plasma is approximately 12 to
16 hours.
Lorazepam is about 90 % bound to plasma proteins. Conjugation with
glucuronic acid to
form the inactive glucuronide of lorazepam is the major metabolic
pathway. Seventy to
seventy five percent of the dose is excreted as the glucuronide in the
urine. Metabolism is
only subject to glucoronidation and is not linked to the action of the
cytochrome P450
enzyme system. The plasma levels of lorazepam are proportional to the
dose given.
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INDICATIONS
TRANQIPAM is