Riik: Ameerika Ühendriigid
keel: inglise
Allikas: NLM (National Library of Medicine)
BUTORPHANOL TARTRATE (UNII: 2L7I72RUHN) (BUTORPHANOL - UNII:QV897JC36D)
Zoetis Inc.
BUTORPHANOL TARTRATE
BUTORPHANOL TARTRATE 2 mg in 1 mL
SUBCUTANEOUS
PRESCRIPTION
TORBUGESIC-SA (butorphanol tartrate injection) is indicated for the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
10 mL vials TORBUGESIC-SA (butorphanol tartrate injection) Veterinary Injection, 2 mg base activity per mL. 10 mL —vials Store at controlled room temperature 20°- 25°C (68°-77°F) with excursions between 15°- 30°C (59°-86°F).
New Animal Drug Application
TORBUGESIC SA- BUTORPHANOL TARTRATE SOLUTION ZOETIS INC. ---------- TORBUGES IC-SA® (BUTORPHANOL TARTRATE INJECTION) Torbugesic-SA® (butorphanol tartrate injection) CIV CAUTION Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Butorphanol tartrate, is a synthetic, centrally acting, narcotic agonist-antagonist analgesic with potent antitussive activity. The results from laboratory and clinical studies suggest the existence of several distinct types of receptors that are responsible for the activity of opioid and opioid-like drugs. When activated, the _μ_(mu)-receptors are involved in analgesia, respiratory depression, miosis, physical dependence and feelings of well-being (euphoria). When activated, the _κ_(kappa)-receptors are involved in analgesia, as well as less intense (as compared to _μ_-receptors) miosis and respiratory depression. Butorphanol is considered to be a weak antagonist at the _μ_-receptor, but a strong agonist at the _κ_- receptor. Thus, butorphanol provides analgesia with a lower incidence and/or intensity of adverse reactions (e.g., miosis and respiratory depression) than traditional opioids. Butorphanol tartrate is a member of the phenanthrene series. The chemical name is Morphinan-3, 14- diol, 17-(cyclobutylmethyl)-, (-)-, (S- (R*, R*))- 2,3- dihydroxybutanedioate (1:1) (salt). It is a white, crystalline, water soluble substance having a molecular weight of 477.55; its molecular formula is C21H29NO2• C4H6O6. CHEMICAL STRUCTURE Each mL of TORBUGESIC-SA contains 2 mg butorphanol base (as butorphanol tartrate, USP); 3.3 mg citric acid, USP; 6.4 mg sodium citrate, USP; 4.7 mg sodium chloride; and 0.1 mg benzethonium chloride; q.s. with water for injection. CLINICAL PHARMACOLOGY FELINE PHARMACOLOGY The magnitude and duration of analgesic activity of butorphanol were studied in cats under controlled laboratory conditions using both a visceral pain model and a somatic pain model.1,2 Subcutaneous butorphanol dosages of 0.4 mg/kg produced Lugege kogu dokumenti