T.O. Prazosin 2 mg Tablet

Riik: Malaisia

keel: inglise

Allikas: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Toimeaine:

PRAZOSIN HYDROCHLORIDE

Saadav alates:

GoodScience Sdn. Bhd.

INN (Rahvusvaheline Nimetus):

PRAZOSIN HYDROCHLORIDE

Ühikuid pakis:

100Tablet Tablets; 250Tablet Tablets

Valmistatud:

T.O. PHARMA CO LTD

Toote omadused

DESCRIPTION:
T.O. Prazosin 1 mg Tablet: An orange, round biconvex tablet with a
breakline on one side. Each tablet contains prazosin hydrochloride
(HCl) 1.095 mg (equivalent to prazosin 1 mg).
T.O. Prazosin 2 mg Tablet: A white round biconvex tablet with a
breakline and a figure “2” on one side and the letters “TOC”
on the
other. Each tablet contains prazosin HCl 2.190 mg (equivalent to
prazosin 2 mg).
PHARMACODYNAMICS
Prazosin is an orally active post-synaptic selective alpha
adrenoceptor
antagonist which reduces peripheral vascular resistance and blood
pressure as a result of its vasodilating effects. It produces both
arterial
and venous dilation.
PHARMACOKINETICS
Prazosin is readily absorbed from the gastrointestinal tract with peak
plasma concentrations occurring 1 to 3 hours after an oral dose. The
bioavailability is variable and a range of 43 to 85 % has been
reported.
Prazosin is highly bound to plasma proteins. It is extensively metabo-
lised in the liver, primarily by demethylation and conjugation and is
excreted, as metabolites and unchanged prazosin (5 to 11 %), mainly
in the faeces via the bile. Less than 10 % is excreted in the urine.
Small
amounts are distributed into breast milk. Its duration of action is
longer than would be predicted from its relatively short plasma
half-life of about 2 to 4 hours. Half-life is reported to be increased
to
about 7 hours in patients with heart failure.
INDICATIONS
Hypertension
T.O. Prazosin 1 mg / 2 mg Tablet is indicated in the treatment of all
grades of essential (primary) hypertension and all grades of second-
ary hypertension of varied aetiology. It can be used as the initial
and
sole agent or it may be employed in a treatment program in conjunc-
tion with a diuretic and/or other antihypertensive drugs, as needed,
for proper patient response.
Left Ventricular Failure
T.O. Prazosin 1 mg / 2 mg Tablet is indicated in the treatment of left
ventricular failure. Prazosin hydrochloride may be added to the thera-
peutic
regimen
in
patients
who
have
not
shown
a