RIMSO-50 SOLUTION

Riik: Kanada

keel: inglise

Allikas: Health Canada

Toimeaine:

DIMETHYL SULFOXIDE

Saadav alates:

MYLAN PHARMACEUTICALS ULC

ATC kood:

G04BX13

INN (Rahvusvaheline Nimetus):

DIMETHYL SULFOXIDE

Annus:

500MG

Ravimvorm:

SOLUTION

Koostis:

DIMETHYL SULFOXIDE 500MG

Manustamisviis:

INTRAVESICAL

Ühikuid pakis:

50ML

Retsepti tüüp:

Prescription

Terapeutiline ala:

MISCELLANEOUS THERAPEUTIC AGENTS

Toote kokkuvõte:

Active ingredient group (AIG) number: 0103075002; AHFS:

Volitamisolek:

APPROVED

Loa andmise kuupäev:

2000-04-04

Toote omadused

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PRODUCT MONOGRAPH
Pr
RIMSO-50
(Dimethyl Sulfoxide 500 mg/g)
Intravesical Instillation for the
TREATMENT OF INTERSTITIAL CYSTITIS
Mylan Pharmaceuticals ULC
85 Advance Road
Etobicoke, ON
M8Z 2S6
Date of Preparation: March 11, 2014
Submission Control No: 171866
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Pr
RIMSO-50
(Dimethyl Sulfoxide 50%)
NOT FOR I.M or I.V Injection
THERAPEUTIC CLASSIFICATION
Intravesical instillation for the treatment of interstitial cystitis.
STRUCTURAL FORMULA AND CHEMISTRY
The active component of RIMSO-50 is dimethyl sulfoxide which has the
empirical formula
C
2
H
6
OS, and is structurally represented as:
Dimethyl sulfoxide is a clear, colorless and essentially odorless
liquid which is miscible with
water and most organic solvents. Other physical characteristics
include: molecular weight 78.13,
melting point 18.4°C, boiling point 189°C, and a specific gravity of
1.100.
ACTION
The mode of action of RIMSO-50 (DMSO) as a treatment for interstitial
cystitis is speculative at
this time. Hypotheses center around the following:
a)
Anti-inflammation
b)
Analgesic
c)
Improvement of blood supply
d)
Softening of collagen due to action on cross-linking
METABOLISM
Dimethyl sulfoxide is metabolised by oxidation to dimethyl sulfone or
by reduction to dimethyl
sulfide. Dimethyl sulfoxide and dimethyl sulfone are excreted in the
urine and feces. Dimethyl
sulfide is eliminated through the breath and skin and is responsible
for the characteristic odor
from patients on dimethyl sulfoxide medication. Dimethyl sulfone can
persist in serum for longer
than two weeks after a single intravesical instillation. No residual
accumulation of dimethyl
sulfoxide has occurred in man or lower animals who have received
treatment for protracted
periods of time. Following topical application, dimethyl sulfoxide is
absorbed and generally
distributed in the tissues and body fluids.
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INDICATIONS AND CLINICAL USES
RIMSO-50 (dimethyl sulfoxide) is indicated for the symptomatic relief
of patients with
interstitial cystitis