Riik: Austraalia
keel: inglise
Allikas: Department of Health (Therapeutic Goods Administration)
Budesonide
AstraZeneca Pty Ltd
Medicine Registered
RHINOCORT(R) 1 RHINOCORT(R) _Budesonide_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Rhinocort. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you using Rhinocort against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT USING RHINOCORT, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH YOUR RHINOCORT. You may need to read it again. WHAT RHINOCORT IS USED FOR ALLERGIC RHINITIS (HAYFEVER) Rhinocort is sprayed into the nose to help prevent and treat allergic rhinitis (hayfever). Hayfever is an inflammation or swelling of the nose lining (which may cause blockage, runny nose, itching and/or sneezing). This is often, but not always, due to an allergy to something in the air (eg pollen, dust mites). You may have symptoms only during spring or summer. This type of allergy is generally due to various pollens. Some people may experience symptoms all year round. This is usually caused by house dust mites, pets or moulds. NASAL POLYPS Rhinocort is also used to treat nasal polyps, which are small masses of tissue that grow from the nose lining. Rhinocort contains budesonide. This belongs to a family of medicines called corticosteroids, which are used to help reduce inflammation. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY RHINOCORT HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. Rhinocort is not addictive. Rhinocort is available only with a doctor's prescription. BEFORE YOU USE RHINOCORT _WHEN YOU MUST NOT USE IT_ DO NOT USE RHINOCORT IF: 1. YOU HAVE AN ALLERGY TO: * any medicines containing budesonide * any of the ingredients listed at the end of this leaflet. Some of the symptoms of an aller Lugege kogu dokumenti
Rhinocort ® Product Information 1 (8) RHINOCORT ® PRODUCT INFORMATION (budesonide for nasal inhalation) NAME OF THE DRUG The active ingredient, budesonide, is a non-halogenated glucocorticoid structurally related to 16a hydroxyprednisolone. The chemical name is 16 α, 17α - 22 R, S-propylmethylenedioxypregna - 1, 4 - diene - 11ß, 21-diol-3, 20-dione; MW 430.5. O H 3 C HO H 3 C C CH 2 OH O O C O H CH 2 CH 2 CH 3 CAS Number: 51333-22-3 DESCRIPTION Budesonide is a white to off-white powder, freely soluble in chloroform, sparingly soluble in ethanol and practically insoluble in water and heptane. Budesonide melts between 224°C and 231.5°C with decomposition. RHINOCORT is available as a 64 μg per dose aqueous nasal suspension containing budesonide as the active ingredient with disodium edetate, potassium sorbate, glucose anhydrous, dispersible cellulose, polysorbate 80 and purified water. The pH of the solution may have been adjusted by hydrochloric acid, if required. _ _ PHARMACOLOGY Studies in animals and humans have shown an advantageous ratio between topical anti-inflammatory activity and systemic glucocorticoid effect over a wide dose range. Budesonide is approximately twice as potent as beclomethasone dipropionate as shown in the skin blanching test for anti-inflammatory activity of topical steroids in humans. Budesonide has, however, less systemic effect than beclomethasone dipropionate, as measured by depression of morning plasma cortisol and effect on differential WBC count. The improved ratio of topical anti-inflammatory activity to systemic effect of budesonide is due to high glucocorticoid receptor affinity combined with a high first pass metabolism and a short half-life. apprhi6410509 Rhinocort ® Product Information 2 (8) Pre-treatment for one week with intranasal budesonide 400 μg daily in asymptomatic patients with seasonal rhinitis, significantly inhibited the immediate reaction Lugege kogu dokumenti