Riik: Ameerika Ühendriigid
keel: inglise
Allikas: NLM (National Library of Medicine)
Pyridostigmine Bromide (UNII: KVI301NA53) (Pyridostigmine - UNII:19QM69HH21)
KAISER FOUNDATION HOSPITALS
Pyridostigmine Bromide
Pyridostigmine Bromide 60 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
PYRIDOSTIGMINE BROMIDE- PYRIDOSTIGMINE BROMIDE TABLET KAISER FOUNDATION HOSPITALS ---------- PYRIDOSTIGMINE BROMIDE TABLETS, USP 60 MG RX ONLY DESCRIPTION: Pyridostigmine Bromide Tablet is an orally active cholinesterase inhibitor. Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. The molecular formula of pyridostigmine bromide is C H BrN O and molecular weight is 261.12. Its structural formula is: Each Pyridostigmine Bromide Tablet intended for oral administration contains 60 mg of Pyridostigmine Bromide USP. In addition, it also contains the following inactive ingredients: colloidal silicon dioxide, anhydrous lactose and stearic acid. CLINICAL PHARMACOLOGY Pyridostigmine Bromide Tablets inhibits the destruction of acetylcholine by cholinesterase and thereby permits freer transmission of nerve impulses across the neuromuscular junction. Pyridostigmine is an analog of neostigmine, but differs from it in certain clinically significant respects; for example, pyridostigmine is characterized by a longer duration of action and fewer gastrointestinal side effects. INDICATIONS AND USAGE Pyridostigmine Bromide Tablets are useful in the treatment of myasthenia gravis. CONTRAINDICATIONS Pyridostigmine Bromide Tablets are contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below. WARNINGS Although failure of patients to show clinical improvement may reflect underdosage, it can also be indicative of overdosage. As is true of all cholinergic drugs, overdosage of Pyridostigmine Bromide Tablets may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death. Myasthenic crisis due to an increase in the severity of the disease is also accompanied by extreme muscle weakness, and thus may be diff Lugege kogu dokumenti