PRAZOSIN HYDROCHLORIDE capsule

Riik: Ameerika Ühendriigid

keel: inglise

Allikas: NLM (National Library of Medicine)

Toimeaine:

PRAZOSIN HYDROCHLORIDE (UNII: X0Z7454B90) (PRAZOSIN - UNII:XM03YJ541D)

Saadav alates:

REMEDYREPACK INC.

INN (Rahvusvaheline Nimetus):

PRAZOSIN HYDROCHLORIDE

Koostis:

PRAZOSIN 2 mg

Retsepti tüüp:

PRESCRIPTION DRUG

Volitamisolek:

Abbreviated New Drug Application

Toote omadused

PRAZOSIN HYDROCHLORIDE- PRAZOSIN HYDROCHLORIDE CAPSULE
REMEDYREPACK INC.
----------
DESCRIPTION
Prazosin hydrochloride capsules, USP a quinazoline derivative, is the
first of a new chemical class of
antihypertensives. It is the hydrochloride salt of
1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)
piperazine and its structural formula is:
Molecular formula is C
H
N
O
• HCl
It is a white to tan powder, slightly soluble in water and methanol,
very slightly soluble in alcohol,
practically insoluble in chloroform and acetone and has a molecular
weight of 419.87. Each capsule,
for oral administration, contains prazosin hydrochloride, USP
equivalent (as the polyhydrate) to 1 mg, 2
mg or 5 mg of prazosin.
Inert ingredients in the formulations are: colloidal silicon dioxide,
lactose monohydrate, magnesium
stearate and microcrystalline cellulose. The empty gelatin capsules
contain black iron oxide, gelatin,
red iron oxide, titanium dioxide and yellow iron oxide. In addition,
the 1 mg empty gelatin capsules
contain D&C Yellow No. 10 and FD&C Green No. 3; the 2 mg empty gelatin
capsules contain D&C
Red No. 28, D&C Yellow No. 10, FD&C Blue No. 1 and FD&C Red No. 40;
and the 5 mg empty
gelatin capsules contain FD&C Blue No. 1.
The imprinting ink also contains ammonium hydroxide, propylene glycol,
shellac glaze, simethicone and
titanium dioxide.
CLINICAL PHARMACOLOGY
The exact mechanism of the hypotensive action of prazosin is unknown.
Prazosin causes a decrease in
total peripheral resistance and was originally thought to have a
direct relaxant action on vascular smooth
muscle. Recent animal studies, however, have suggested that the
vasodilator effect of prazosin is also
related to blockade of postsynaptic alpha _-_adrenoceptors. The
results of dog forelimb experiments
demonstrate that the peripheral vasodilator effect of prazosin is
confined mainly to the level of the
resistance vessels (arterioles). Unlike conventional alpha
_-_blockers, the antihypertensive action of
prazosin is usually not accompanied by a reflex ta