LIDOCAINE HYDROCHLORIDE solution

Riik: Ameerika Ühendriigid

keel: inglise

Allikas: NLM (National Library of Medicine)

Toimeaine:

LIDOCAINE HYDROCHLORIDE (UNII: V13007Z41A) (LIDOCAINE - UNII:98PI200987)

Saadav alates:

LLC Federal Solutions

INN (Rahvusvaheline Nimetus):

LIDOCAINE HYDROCHLORIDE

Koostis:

LIDOCAINE HYDROCHLORIDE ANHYDROUS 20 mg in 1 mL

Manustamisviis:

ORAL

Retsepti tüüp:

PRESCRIPTION DRUG

Näidustused:

INDICATIONS AND USAGE Lidocaine Hydrochloride Oral Topical Solution, USP (Viscous) 2% is indicated for the production of topical anesthesia of irritated or inflamed mucous membranes of the mouth and pharynx. It is also useful for reducing gagging during the taking of X-ray pictures and dental impressions. CONTRAINDICATIONS Lidocaine is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type, or to other components of the solution. Pediatric use Dosages in children should be reduced, commensurate with age, body weight and physical condition. (See DOSAGE AND ADMINISTRATION).

Toote kokkuvõte:

HOW SUPPLIED Lidocaine Hydrochloride Oral Topical Solution, USP (Viscous) 2% is a clear, viscous liquid with a very slight orange flavor available in 20 mL unit dose cups. One-hundred (100) cups per box. SHAKE WELL BEFORE USE. Repackaged by: Safecor Health, LLC 317 New Boston St. Woburn, MA 01801 Rev 101-00 07/2013 Distributed by: LLC Federal Solutions Miami, FL 33132

Volitamisolek:

Abbreviated New Drug Application

Toote omadused

LIDOCAINE HYDROCHLORIDE- LIDOCAINE HYDROCHLORIDE SOLUTION
LLC FEDERAL SOLUTIONS
----------
A Topical Anesthetic for the Mucous Membranes of the Mouth and
Pharynx.
FOR ORAL USE ONLY.
RX ONLY
DESCRIPTION
Lidocaine Hydrochloride Oral Topical Solution, USP (Viscous) 2%
contains a local anesthetic agent
and is administered topically. Lidocaine Hydrochloride Oral Topical
Solution, USP (Viscous) 2%
contains lidocaine hydrochloride, which is chemically designated as
acetamide, 2-(diethylamino)-N-
(2,6-dimethylphenyl)- , monohydrochloride and has the following
structural formula:
The molecular formula of lidocaine is C
H N O. The molecular weight is 234.34.
Each mL contains 20 mg of lidocaine HCl. In addition each mL contains
the following inactive
ingredients: Carboxymethylcellulose sodium, methylparaben, natural
orange flavor, propylparaben,
purified water, saccharin sodium. The pH is adjusted to 5.0 to 7.0 by
means of hydrochloric acid and/or
sodium hydroxide.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION:
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic
fluxes required for the initiation and
conduction of impulses, thereby effecting local anesthetic action.
HEMODYNAMICS:
Excessive blood levels may cause changes in cardiac output, total
peripheral resistance, and mean
arterial pressure. These changes may be attributable to a direct
depressant effect of the local anesthetic
agent on various components of the cardiovascular system. The net
effect is normally a modest
hypotension when the recommended dosages are not exceeded.
PHARMACOKINETICS AND METABOLISM:
Lidocaine is absorbed following topical administration to mucous
membranes, its rate and extent of
absorption being dependent upon concentration and total dose
administered, the specific site of
application, and duration of exposure. In general, the rate of
absorption of local anesthetic agents
following topical application occurs most rapidly after intratracheal
administration. Lidocaine is also
well-absorbed from the gastrointestinal tract, but little