KADIAN ER morphine sulfate capsule

Riik: Ameerika Ühendriigid

keel: inglise

Allikas: NLM (National Library of Medicine)

Toimeaine:

MORPHINE SULFATE (UNII: X3P646A2J0) (MORPHINE - UNII:76I7G6D29C)

Saadav alates:

St Marys Medical Park Pharmacy

INN (Rahvusvaheline Nimetus):

MORPHINE SULFATE

Koostis:

MORPHINE SULFATE 20 mg

Retsepti tüüp:

PRESCRIPTION DRUG

Volitamisolek:

New Drug Application

Toote omadused

KADIAN ER - MORPHINE SULFATE CAPSULE
ST MARYS MEDICAL PARK PHARMACY
----------
KADIAN ER
BOXED WARNING
KADIAN® contains morphine sulfate, an opioid agonist and a Schedule
II controlled substance,
with an abuse liability similar to other opioid analgesics. KADIAN®
can be abused in a manner
similar to other opioid agonists, legal or illicit. This should be
considered when prescribing or
dispensing KADIAN® in situations where the physician or pharmacist is
concerned about an
increased risk of misuse, abuse or diversion.
KADIAN® capsules are an extended-release oral formulation of morphine
sulfate indicated for
the management of moderate to severe pain when a continuous,
around-the-clock opioid analgesic
is needed for an extended period of time.
KADIAN® Capsules are NOT for use as a prn analgesic.
KADIAN® 100 mg and 200 mg Capsules ARE FOR USE IN OPIOID-TOLERANT
PATIENTS
ONLY. Ingestion of these capsules or of the pellets within the
capsules may cause fatal
respiratory depression when administered to patients not already
tolerant to high doses of
opioids. KADIAN® CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS
OF THE CAPSULES SPRINKLED ON APPLE SAUCE. THE PELLETS IN THE CAPSULES
ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED DUE TO THE RISK OF RAPID
RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE OF MORPHINE.
DESCRIPTION
KADIAN® (morphine sulfate) capsules are an opioid analgesic supplied
in 10 mg, 20 mg, 30 mg, 50
mg, 60 mg, 80 mg, 100 mg, and 200 mg strengths for oral
administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5
α-epoxy-17-methyl-morphinan-3,6 α-diol sulfate
(2:1) (salt) pentahydrate and has the following structural formula:
Morphine sulfate is an odorless, white, crystalline powder with a
bitter taste and a molecular weight of
758 (as the sulfate). It has a solubility of 1 in 21 parts of water
and 1 in 1000 parts of alcohol, but is
practically insoluble in chloroform or ether. The octanol: water
partition coefficient of morphine is
1.42 at physiologic pH and the pKb is 7.9 for the