Riik: Ameerika Ühendriigid
keel: inglise
Allikas: NLM (National Library of Medicine)
ITRACONAZOLE (UNII: 304NUG5GF4) (ITRACONAZOLE - UNII:304NUG5GF4)
Eon Labs, Inc.
ITRACONAZOLE
ITRACONAZOLE 100 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
ITRACONAZOLE- ITRACONAZOLE CAPSULE EON LABS, INC. ---------- ITRACONAZOLE CAPSULES, 100 MG RX ONLY BOXED WARNING CONGESTIVE HEART FAILURE, CARDIAC EFFECTS AND DRUG INTERACTIONS ITRACONAZOLE CAPSULES SHOULD NOT BE ADMINISTERED FOR THE TREATMENT OF ONYCHOMYCOSIS IN PATIENTS WITH EVIDENCE OF VENTRICULAR DYSFUNCTION SUCH AS CONGESTIVE HEART FAILURE (CHF) OR A HISTORY OF CHF. IF SIGNS OR SYMPTOMS OF CONGESTIVE HEART FAILURE OCCUR DURING ADMINISTRATION OF ITRACONAZOLE CAPSULES, DISCONTINUE ADMINISTRATION. WHEN ITRACONAZOLE WAS ADMINISTERED INTRAVENOUSLY TO DOGS AND HEALTHY HUMAN VOLUNTEERS, NEGATIVE INOTROPIC EFFECTS WERE SEEN. (See CONTRAINDICATIONS; WARNINGS; PRECAUTIONS, DRUG INTERACTIONS; ADVERSE REACTIONS, POST-MARKETING EXPERIENCE and CLINICAL PHARMACOLOGY, SPECIAL POPULATIONS for more information.) DRUG INTERACTIONS COADMINISTRATION OF THE FOLLOWING DRUGS ARE CONTRAINDICATED WITH ITRACONAZOLE CAPSULES: METHADONE, DISOPYRAMIDE, DOFETILIDE, DRONEDARONE, QUINIDINE, ERGOT ALKALOIDS [(SUCH AS DIHYDROERGOTAMINE, ERGOMETRINE (ERGONOVINE), ERGOTAMINE, METHYLERGOMETRINE (METHYLERGONOVINE)], IRINOTECAN, LURASIDONE, ORAL MIDAZOLAM, PIMOZIDE, TRIAZOLAM, FELODIPINE, NISOLDIPINE, IVABRADINE, RANOLAZINE, EPLERENONE, CISAPRIDE, LOVASTATIN, SIMVASTATIN, TICAGRELOR AND, IN SUBJECTS WITH VARYING DEGREES OF RENAL OR HEPATIC IMPAIRMENT, COLCHICINE, FESOTERODINE, TELITHROMYCIN AND SOLIFENACIN. SEE PRECAUTIONS, DRUG INTERACTIONS SECTION FOR SPECIFIC EXAMPLES. COADMINISTRATION WITH ITRACONAZOLE CAN CAUSE ELEVATED PLASMA CONCENTRATIONS OF THESE DRUGS AND MAY INCREASE OR PROLONG BOTH THE PHARMACOLOGIC EFFECTS AND/OR ADVERSE REACTIONS TO THESE DRUGS. FOR EXAMPLE, INCREASED PLASMA CONCENTRATIONS OF SOME OF THESE DRUGS CAN LEAD TO QT PROLONGATION AND VENTRICULAR TACHYARRHYTHMIAS INCLUDING OCCURRENCES OF _TORSADES DE POINTES_, A POTENTIALLY FATAL ARRHYTHMIA. SEE CONTRAINDICATIONS AND WARNINGS SECTIONS, AND PRECAUTIONS, DRUG INTERACTIONS SECTION FOR SPECIFIC EXAMPLES. DESCRIPTION Itraconazole is an azole antifungal agent. Itraconazole is a 1: Lugege kogu dokumenti