Riik: Malaisia
keel: inglise
Allikas: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Bromhexine HCl; DEXTROMETHORPHAN HYDROBROMIDE
HOVID BERHAD
Bromhexine HCl; DEXTROMETHORPHAN HYDROBROMIDE
120ml mL; 60ml mL; 60 mL; 120 mL
HOVID BERHAD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ HOSOLVON DM ELIXIR (SUGAR FREE) Bromhexine Hydrochloride / Dextromethorphan Hydrobromide (4mg/15 mg) 1 WHAT IS IN THIS LEAFLET 1. What Hosolvon DM Elixir (Sugar Free) is used for 2. How Hosolvon DM Elixir (Sugar Free) works 3. Before you use Hosolvon DM Elixir (Sugar Free) 4. How to use Hosolvon DM Elixir (Sugar Free) 5. While you are using Hosolvon DM Elixir (Sugar Free) 6. Side effects 7. Storage and Disposal of Hosolvon DM Elixir (Sugar Free) 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT HOSOLVON DM ELIXIR (SUGAR FREE) IS USED FOR To relief cough temporarily and reduce mucus thickness. HOW HOSOLVON DM ELIXIR (SUGAR FREE) WORKS The active ingredients in this medicine are bromhexine hydrochloride and dextromethorphan hydrobromide. Bromhexine hydrochloride is a mucolytic used to reduce mucus thickness. Dextromethorphan hydrobromide is a cough suppressant. It inhibits the signal in the brain that causes cough. BEFORE YOU USE HOSOLVON DM ELIXIR (SUGAR FREE) - _When you must not use it_ Do not take this medicine if: • you are allergic to bromhexine, dextromethorphan or any of the ingredients listed in the end of this leaflet • you are pregnant or breastfeeding • your children are less than 2 years of age If you are not sure whether you should start taking this medicine, talk to your pharmacist or doctor. _- Before you start to use it _ Tell your doctor/pharmacist if: • you have history of asthma • you have history of gastric ulcer • you have severe liver and kidney problems • you have respiratory problem • your children aged between 2 to 6 are going to use it • you are pregnant, think you are pregnant or plan to get pregnant • you are breastfeeding or plan to breastfeed _- Taking other medicines _ Hosolvon DM Elixir (Sugar Free) may affect or affected by other medicines you are taking. Talk to your doctor or pharmacist if you are taking any other medicines in any form including any that you buy or Lugege kogu dokumenti
DESCRIPTION Green, vanillin and peppermint flavoured liquid. COMPOSITION Each 5 ml contains: Bromhexine Hydrochloride 4 mg Dextromethorphan Hydrobromide 15 mg _Preservatives:_ Methyl Paraben 0.12% w/v Propyl Paraben 0.02% w/v ACTIONS AND PHARMACOLOGY Bromhexine is a mucolytic used in the treatment of respiratory disorders associated with productive cough, where it changes the structure of bronchial secretions leading to a reduction in the viscosity of sputum. Dextromethorphan Hydrobromide is a cough suppressant used for the relief of non-productive cough. It has a central action on the cough centre in the medulla. It is also an antagonist of N-methyl-D-aspartate (NMDA) receptors. Dextromethorphan has no classical analgesic properties and little sedative activity. PHARMACOKINETICS Bromhexine is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. It is widely distributed to body tissues. About 85 to 90% of a dose is excreted in the urine mainly as metabolites. Bromhexine is highly bound to plasma proteins and has a terminal elimination half-life of up to about 12 hours. It crosses the blood-brain barrier and small amounts cross the placenta. Dextromethorphan Hydrobromide is rapidly absorbed from the gastrointestinal tract. It is metabolized in the liver excreted in the urine as unchanged dextromethorphan and demethylated metabolites including dextrorphan. It is reported to act within half an hour of administration by mouth and to exert an effect for up to 6 hours. INDICATIONS For short term symptomatic relief of cough associated with reduction in sputum viscosity. CONTRAINDICATIONS This medication is contraindicated with patients with sensitivity to bromhexine and dextromethorphan or other components of the formulation. The presence of other medical problems may affect the use of this medication. A doctor should be consulted before using this medicine if any other medical problems exist, especially: peptic ulceration, asthma, chronic bronchitis, productive co Lugege kogu dokumenti