FORTZAAR TABLET

Riik: Lõuna-Aafrika Vabariik

keel: inglise

Allikas: South African Health Products Regulatory Authority (SAHPRA)

Saadav alates:

Organon South Africa (Pty) Ltd

Annus:

See ingredients

Ravimvorm:

TABLET

Koostis:

EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 25,0 mg LOSARTAN POTASSIUM 100,0 mg

Volitamisolek:

Registered

Loa andmise kuupäev:

2002-08-02

Infovoldik

1
APPROVED PATIENT INFORMATION LEAFLET:
INFORMATION FOR THE PATIENT ABOUT FORTZAAR

READ ALL OF THIS LEAFLET CAREFULLY BEFORE YOU START TAKING FORTZAAR

Keep this leaflet. You may need to read it again

If you have further questions, please ask your doctor or your
pharmacist.

FORTZAAR has been prescribed for you personally and you should not
share your medicine with
other people. It may harm them, even if their symptoms are the same as
yours.
SCHEDULING STATUS
S3
PROPRIETARY NAME AND DOSAGE FORM
FORTZAAR

TABLET
(100 mg losartan potassium and 25 mg hydrochlorothiazide)
WHAT FORTZAAR CONTAIN
FORTZAAR (losartan potassium-hydrochlorothiazide) are film-coated
tablets containing 100 mg of losartan
potassium and 25 mg of hydrochlorothiazide as the active ingredients.
In addition, FORTZAAR contain the following inactive ingredients:
Quinoline yellow aluminium lake; carnauba wax; hydroxypropyl
cellulose; hypromellose; lactose hydrous;
magnesium stearate; microcrystalline cellulose; pregelatinised starch;
titanium dioxide.
FORTZAAR contains lactose hydrous
WHAT FORTZAAR IS USED FOR
FORTZAAR is a combination of angiotensin II receptor antagonist
(losartan) and a diuretic (hydrochlorothiazide).
Losartan and hydrochlorothiazide work together to lower high blood
pressure.
Your doctor has prescribed FORTZAAR because you have a condition known
as hypertension or high blood
pressure.
BEFORE YOU TAKE FORTZAAR
Copyright

2005 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.,
Whitehouse Station, NJ, U.S.A
2
DO NOT TAKE FORTZAAR:

If you are allergic to any of its ingredients (see WHAT FORTZAAR
CONTAIN)

If you have previously been treated with a medication in the same
group of medicines as FORTZAAR
(angiotensin receptor antagonists) or with a medication in the group
of medicines known as ACE
inhibitors and have had allergic reactions with swelling of the face,
lips, tongue, and/or throat with
difficulty in swallowing or breathing.

If you have hereditary or idiopathic angioedema

If you ha

Toote omadused

1
SCHEDULING STATUS
S3
PROPRIETARY NAME AND DOSAGE FORM
FORTZAAR

Tablet
COMPOSITION
Each FORTZAAR Tablet contains 100 mg losartan potassium and 25 mg
hydrochlorothiazide.
FORTZAAR contains 8, 48 mg (0,216 mEq) of potassium.
FORTZAAR contains lactose
In addition, FORTZAAR contain the following inactive ingredients:
Quinoline yellow aluminium lake; carnauba wax; hydroxypropyl
cellulose; hypromellose; lactose hydrous;
magnesium stearate; microcrystalline cellulose; pregelatinised starch;
titanium dioxide.
PHARMACOLOGICAL CLASSIFICATION
A 7.1.3. Other hypotensives
PHARMACOLOGICAL ACTION
Losartan potassium is an angiotensin II receptor (type AT
1
) antagonist and hydrochlorothiazide is a diuretic.
LOSARTAN
Angiotensin II, a potent vasoconstrictor, is the primary active
hormone of the renin-angiotensin system, and a
major determinant of the pathophysiology of hypertension. Angiotensin
II binds to the AT
1
receptor found in
many tissues (e.g., vascular smooth muscle, adrenal gland, kidneys,
and the heart) and elicits several important
biological actions, including vasoconstriction and the release of
aldosterone. Angiotensin II also stimulates
smooth muscle cell proliferation.

Copyright

2005 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.,
Whitehouse Station, NJ, U.S.A
2
Losartan is a synthetic, orally active compound which binds
selectively to the AT
1
receptor. Both losartan and its
pharmacologically active carboxylic acid metabolite (E-3174) block the
actions of angiotensin II, regardless of the
source of synthesis.
HYDROCHLOROTHIAZIDE
The mechanism of the antihypertensive effect of thiazides is unknown.
Hydrochlorothiazide, when used as a diuretic affects the distal renal
tubular mechanism of electrolyte
reabsorption. Hydrochlorothiazide increases excretion of sodium and
chloride in approximately equivalent
amounts. Natriuresis may be accompanied by loss of potassium,
magnesium and bicarbonate.
LOSARTAN POTASSIUM-HYDROCHLOROTHIAZIDE
Losartan and hydrochlorothiazide are additive in their
antih