COXICIN

Riik: Malaisia

keel: inglise

Allikas: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Toimeaine:

PYRIMETHAMINE; Sulfaquinoxaline/Suphaquinoxaline Sodium

Saadav alates:

RANGE PHARMA SDN. BHD.

INN (Rahvusvaheline Nimetus):

PYRIMETHAMINE; Sulfaquinoxaline/Suphaquinoxaline Sodium

Ühikuid pakis:

1.00 L; 5.00 L

Valmistatud:

RANGE PHARMA SDN. BHD.

Toote omadused

COXICIN SOLUTION
DESCRIPTION AND COMPOSITION
COXICIN is a yellow clear viscous solution.
30mg Sulfaquinoxaline sodium and 10 mg Pyrimethamine per ml.
PHARMACODYNAMICS
Sulfaquinoxaline is an antiprotozoal agent used to combat coccidial
infections of swine, cattle, fowl, and other veterinary animals.
Sulfaquinoxaline
prevents the production of folic acid in the bacterial and protozoal
cell by inhibiting the utilisation of para-aminobenzoice acid.
Synthesis of folic acid
is essential for the survival of the bacterial and protozoal cell.
Pathogenic bacteria and protozoa synthesise folic acid from
para-aminobenzoic acid,
whereas animal cells incorporate folic acid from the food; animal
cells are not therefore directly affected by Sulfaquinoxaline
medication.
Pyrimethamine is a medication used for protozoal infections. It is
commonly used as an antimalarial drug (for both treatment and
prevention).
Pyrimethamine is a folic acid antagonist and the rationale for its
therapeutic action is based on the differential requirement between
host and parasite
for nucleic acid precursors involved in growth. This activity is
highly selective against plasmodia and Toxoplasma gondii.
PHARMACOKINETICS
Sulfaquinoxaline is minimally absorbed systemically and is referred to
as an enteric sulfonamide.
Pyrimethamine reversibly binds to and inhibits the enzyme
dihydrofolate reductase in protozoa. This inhibition prevents the
production of
tetrahydrofolic acid from dihydrofolate and thereby prevents the
metabolism of folate. Like protozoa, mammalian cells reduce folic acid
to
tetrahydrofolic acid; however, the therapeutic action of pyrimethamine
relies on a greater selectivity for protozoal dihydrofolate reductase
than for
the mammalian enzyme. Pyrimethamine is generally administered in
conjunction with a sulfonamide to take advantage of the sequential
inhibition of
enzymatic steps in folate synthesis provided by the combination.
INDICATION
For the treatment of gastrointestinal infections caused by coccidia in
poultry.
RECOMMENDED DOSE
Mix o