Riik: Kanada
keel: inglise
Allikas: Health Canada
NADOLOL
BRISTOL-MYERS SQUIBB CANADA
C07AA12
NADOLOL
80MG
TABLET
NADOLOL 80MG
ORAL
100
Prescription
BETA-ADRENERGIC BLOCKING AGENTS
Active ingredient group (AIG) number: 0113396001; AHFS:
CANCELLED POST MARKET
2006-10-25
PRODUCT MONOGRAPH PR CORGARD* (NADOLOL) TABLETS, USP, 40 & 80 MG ANTI-ANGINAL AND ANTI-HYPERTENSIVE AGENT Bristol-Myers Squibb Canada 2365 Cote de Liesse Montreal, Canada Date of Preparation: H4N 2M7 October 27, 2004 * TM of Bristol-Myers Squibb Canada Date of Revision: Control#: 094847 1 PRODUCT MONOGRAPH NAME OF DRUG PR CORGARD (NADOLOL) Tablets, USP, 40 & 80 mg THERAPEUTIC CLASSIFICATION Anti-anginal and Anti-hypertensive Agent ACTIONS AND CLINICAL PHARMACOLOGY CORGARD (nadolol) is a non-cardio-selective beta-adrenergic blocking agent. It does not possess membrane stabilizing or intrinsic sympathomimetic (partial agonist) activities. The exact mechanism by which CORGARD exercises its antianginal effect is not certain. An important factor may be the reduction of myocardial oxygen requirements by blocking catecholamine-induced increases in heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction. However, oxygen requirements may be increased by such actions as increases in left ventricular fibre length, end diastolic pressure and the systolic ejection period. When the net physiological effect is advantageous in anginal patients, it manifests itself during exercise or stress by delaying the onset of pain and reducing the incidence and severity of anginal attacks. CORGARD can therefore increase the capacity for work and exercise in such patients. The mechanism of the antihypertensive effect of CORGARD has not yet been established. Among the factors that may be involved are: (a) Competitive ability to antagonize catecholamine-induced tachycardia at the beta-receptor sites in the heart, thus decreasing cardiac output. (b) Inhibition of renin release by the kidneys. (c) Inhibition of vasomotor centers. PHARMACOKINETICS 2 In humans, approximately 37% of orally-administered nadolol is slowly absorbed. Approximately 30% of the nadolol present in serum is reversibly bound to plasma proteins and the drug is extensively distributed to extravascular tissues. Maximum serum concentrations are Lugege kogu dokumenti