Riik: Malaisia
keel: inglise
Allikas: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
SILDENAFIL CITRATE
RANBAXY (MALAYSIA) SDN. BHD.
SILDENAFIL CITRATE
10Tablet Tablets; 60Tablet Tablets; 30Tablet Tablets; 100Tablet Tablets
RANBAXY (MALAYSIA) SDN. BHD.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ CAVERTA TABLETS Sildenafil (100 mg) page. 1 WHAT IS IN THIS LEAFLET 1. What CAVERTA is used for 2. How CAVERTA works 3. Before you take CAVERTA 4. How to take CAVERTA 5. While you are taking it 6. Side Effects 7. Storage and Disposal of CAVERTA 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT CAVERTA IS USED FOR CAVERTA is used for the treatment for adult men with erectile dysfunction, sometimes known as impotence. This is when a man cannot get, or keep a hard, erect penis suitable for sexual activity. HOW CAVERTA WORK CAVERTA contains the active substance sildenafil, which belongs to a group of medicines called phosphodiesterase type 5 inhibitors. It works by helping to relax the blood vessels in your penis, allowing blood to flow into your penis when you get sexually excited. CAVERTA will only help you to get an erection if you are sexually stimulated. BEFORE YOU TAKE CAVERTA _ _ _When you must not take it _ If you are allergic (hypersensitive) to sildenafil or any of the other ingredients of CAVERTA . If you are suffering with severe cardiovascular disorders such as unstable angina or severe cardiac failure If you are taking medicines containing nitrates, nitrites or nitric oxide donors. If you are taking riociguat. This medicine is used to treat pulmonary arterial hypertension (i.e., high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (i.e., high blood pressure in the lungs caused by blood clots). If you have or ever had a sudden decrease or loss of vision because of a problem with blood flow to the nerve in the eye called non- arteritic anterior ischaemic optic neuropathy (NAION). If you have a severe liver problem. If you have recently had a stroke or a heart attack, or if you have low blood pressure. If you have certain rare inherited eye diseases (such as retinitis pigmentosa). _Before you start to take it _ Tell your doctor If you have sick Lugege kogu dokumenti
_For the use only of a Registered Medical Practitioner _ CAVERTA TABLETS 50/100 MG (Sildenafil Tablets) COMPOSITION CAVERTA TABLETS 50 MG Each film-coated tablet contains: Sildenafil Citrate 70.24 mg equivalent to Sildenafil....................... 50 mg. CAVERTA TABLETS 100 MG Each film-coated tablet contains: Sildenafil Citrate 140.48 mg equivalent to Sildenafil....................... 100 mg. PRODUCT DESCRIPTION CAVERTA TABLETS 50 MG Red coloured, rounded triangular shaped, film-coated tablet, with ‘S22’ engraved on one side and break line on the other side CAVERTA TABLETS 100 MG Red coloured, rounded triangular shaped, film-coated tablet, with ‘S23’ engraved on one side and break line on the other side DESCRIPTION CAVERTA TABLETS contain citrate salt of sildenafil, which is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Sildenafil citrate is chemically designated as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1_H_-_ _ pyrazolo[4,3-_d_]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate. Its molecular weight is 666.7. Its empirical formula is C 22 H 30 N 6 O 4 S.C 6 H 8 O 7 . It has the following structural formula: SILDENAFIL CITRATE PHARMACOLOGY • MECHANISM OF ACTION The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation Lugege kogu dokumenti