CARPROVET- carprofen flavored tablet

Riik: Ameerika Ühendriigid

keel: inglise

Allikas: NLM (National Library of Medicine)

Toimeaine:

CARPROFEN (UNII: FFL0D546HO) (CARPROFEN - UNII:FFL0D546HO)

Saadav alates:

Dechra Veterinary Products

INN (Rahvusvaheline Nimetus):

CARPROFEN

Koostis:

CARPROFEN 25 mg

Manustamisviis:

ORAL

Retsepti tüüp:

PRESCRIPTION

Näidustused:

Carprovet is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprovet should not be used in dogs exhibiting previous hypersensitivity to carprofen.

Toote kokkuvõte:

Carprovet (carprofen) flavored tablets are scored, and contain 25 mg, 75 mg, or 100 mg of carprofen per tablet. Each tablet size is packaged in bottles containing 60 or 180 tablets. Carprovet (carprofen) Flavored Tablets 25 mg, 60 tablets NDC 17033-359-60 Carprovet (carprofen) Flavored Tablets 25 mg, 180 tablets NDC 17033-359-18 Carprovet (carprofen) Flavored Tablets 75 mg, 60 tablets NDC 17033-360-60 Carprovet (carprofen) Flavored Tablets 75 mg, 180 tablets NDC 17033-360-18 Carprovet (carprofen) Flavored Tablets 100 mg, 60 tablets NDC 17033-358-60 Carprovet (carprofen) Flavored Tablets 100 mg, 180 tablets NDC 17033-358-18

Volitamisolek:

Abbreviated New Animal Drug Application

Toote omadused

CARPROVET- CARPROFEN FLAVORED TABLET
DECHRA VETERINARY PRODUCTS
----------
CARPROVET (CARPROFEN) FLAVORED TABLETS
_NON-STEROIDAL ANTI-INFLAMMATORY DRUG_
FOR ORAL USE IN DOGS ONLY
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Carprovet (carprofen) is a non-steroidal anti-inflammatory drug
(NSAID) of the propionic acid class
that includes ibuprofen, naproxen, and ketoprofen. Carprofen is the
nonproprietary designation for a
substituted carbazole, 6-chloro-α-methyl-9H-carbazole-2-acetic acid.
The empirical formula is
C
H ClNO and the molecular weight 273.72. The chemical structure of
carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically insoluble in
water at 25°C.
CLINICAL PHARMACOLOGY
Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent
with characteristic analgesic and
antipyretic activity approximately equipotent to indomethacin in
animal models.
The mechanism of action of carprofen, like that of other NSAIDs, is
believed to be associated with the
inhibition of cyclooxygenase activity. Two unique cyclooxygenases have
been described in mammals.
The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins
necessary for normal
gastrointestinal and renal function. The inducible cyclooxygenase,
COX-2, generates prostaglandins
involved in inflammation. Inhibition of COX-1 is thought to be
associated with gastrointestinal and renal
toxicity while inhibition of COX-2 provides anti-inflammatory
activity. The specificity of a particular
NSAID for COX-2 versus COX-1 may vary from species to species.
In an_ in vitro _study using canine
cell cultures, carprofen demonstrated selective inhibition of COX-2
versus COX-1.
Clinical relevance
of these data has not been shown. Carprofen has also been shown to
inhibit the release of several
prostaglandins in two inflammatory cell systems: rat polymorphonuclear
leukocytes (PMN) and human
rheumatoid synovial cells, indicating inhibition of acute (PMN sys