Riik: Kanada
keel: inglise
Allikas: Health Canada
CAPTOPRIL
SORRES PHARMA INC
C09AA01
CAPTOPRIL
50MG
TABLET
CAPTOPRIL 50MG
ORAL
100/500
Prescription
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
Active ingredient group (AIG) number: 0114954002; AHFS:
CANCELLED POST MARKET
2014-06-20
PRODUCT MONOGRAPH CAPTOPRIL (Captopril Tablets USP) 12.5, 25, 50 and 100 mg ANGIOTENSIN-CONVERTING ENZYME INHIBITOR SORRES PHARMA INC. DATE PREPARATION: 6111 Royalmount Ave., Suite 100 April 15, 2010 Montreal, Quebec H4P 2T4 Control#: 137554 2 NAME OF DRUG CAPTOPRIL (Captopril Tablets USP) 12.5, 25, 50 and 100 mg THERAPEUTIC CLASSIFICATION Angiotensin-Converting Enzyme Inhibitor ACTION AND CLINICAL PHARMACOLOGY CAPTOPRIL is an angiotensin converting enzyme inhibitor used in the treatment of hypertension and heart failure. The mechanism of action of captopril has not yet been fully elucidated. It appears to lower blood pressure and be an adjunct in the therapy of congestive heart failure primarily through suppression of the renin-angiotensin-aldosterone system; however, there is no consistent correlation between renin levels and response to the drug. Renin, an enzyme synthesized by the kidneys, is released into the circulation where it acts on plasma globulin substrate to produce angiotensin I, a relatively inactive decapeptide. Angiotensin I is then converted by angiotensin converting enzyme (ACE) to angiotensin II, a potent endogenous vasoconstrictor substance. Angiotensin II also stimulates aldosterone secretion from the adrenal cortex, thereby contributing to sodium and fluid retention. Captopril prevents the conversion of angiotensin I to angiotensin II by inhibition of ACE, a peptidyldipeptide carboxy hydrolase. ACE is identical to "bradykininase" and captopril may also interfere with the degradation of the vasopressor peptide, bradykinin. However, the effectiveness of captopril in therapeutic doses appears to be unrelated to potentiation of the actions of bradykinin. Increased concentrations of bradykinin or prostaglandin E 2 may also have a role in the therapeutic effect of captopril, especially in low-renin hypertension. 3 Inhibition of ACE results in decreased plasma angiotensin II and increased plasma renin activity (PRA), the latter resulting from loss of negative feedback on renin release caused by re Lugege kogu dokumenti